Intraperitoneal Administration of Telmisartan Prevents Postsurgical Adhesion Band Formation

Mohammad Hassan Arjmand, Farnaz Zahedi-Avval, Farnaz Barneh, Seyed Hadi Mousavi, Fereshteh Asgharzadeh, Milad Hashemzehi, Atena Soleimani, Amir Avan, Maryam Fakhraie, Seyedeh Najibeh Nasiri, Saeedeh Mehraban, Gordon A. Ferns, Mikhail Ryzhikov, Mohieddin Jafari, Majid Khazaei, Seyed Mahdi Hassanian

Onderzoeksoutput: Bijdrage aan tijdschriftArtikelpeer review

10 Citaten (Scopus)

Samenvatting

Background: Angiotensin II receptor blockers (ARBs) have a potential role in reducing inflammation and fibrosis. We have integrated systems and molecular biology approaches to investigate the therapeutic potential of ARBs in preventing postsurgical adhesion band formation. Material and methods: we have followed the ARRIVE guidelines point by point during experimental studies. Telmisartan (1 and 9 mg/kg), valsartan (1 and 9 mg/kg), and losartan (1 and 10 mg/kg) were administered intraperitoneally in different groups of male albino Wistar rat. After 7 d of treatment, macroscopic evidence and score of fibrotic bands based on scaling methods was performed. Moreover, the anti-inflammatory and antifibrosis effects of telmisartan on reduction of fibrotic bands were investigated by using histopathology, ELISA, and real-time polymerase chain reaction methods. Results: Telmisartan, but not losartan or valsartan, prevented the frequency as well as the stability of adhesion bands. Telmisartan appears to elicit anti-inflammatory responses by attenuating submucosal edema, suppressing proinflammatory cytokines, decreasing proinflammatory cell infiltration, and inhibiting oxidative stress at the site of peritoneal surgery. We also showed that telmisartan prevents fibrotic adhesion band formation by reducing excessive collagen deposition and suppression of profibrotic genes expression at the peritoneum adhesion tissues. Conclusions: These results support the potential application of telmisartan in preventing postsurgical adhesion band formation by inhibiting key pathologic responses of inflammation and fibrosis in postsurgery patients.

Originele taal-2Engels
Pagina's (van-tot)171-181
Aantal pagina's11
TijdschriftJournal of Surgical Research
Volume248
DOI's
StatusGepubliceerd - apr. 2020
Extern gepubliceerdJa

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