TY - JOUR
T1 - Intrapulmonary posaconazole penetration at the infection site in an immunosuppressed murine model of invasive pulmonary aspergillosis receiving oral prophylactic regimens
AU - Seyedmousavi, Seyedmojtaba
AU - Brüggemann, Roger J.M.
AU - Melchers, Willem J.G.
AU - Verweij, Paul E.
AU - Moutona, Johan W.
PY - 2014/5
Y1 - 2014/5
N2 - Adequate penetration to the infection/colonization site is crucial to attain optimal efficacy of posaconazole against Aspergillus fumigatus diseases. We evaluated posaconazole exposure in pulmonary epithelial lining fluid (ELF) in a murine model of invasive pulmonary aspergillosis. The posaconazole exposure (area under the plasma concentration-time curve from time zero to 24 h postinfusion [AUC0-24]) in ELF was 20% to 31% of that in plasma for total drug after the third dose, and the relationship between plasma and ELF exposure was linear (r2=0.97, P=0.016).
AB - Adequate penetration to the infection/colonization site is crucial to attain optimal efficacy of posaconazole against Aspergillus fumigatus diseases. We evaluated posaconazole exposure in pulmonary epithelial lining fluid (ELF) in a murine model of invasive pulmonary aspergillosis. The posaconazole exposure (area under the plasma concentration-time curve from time zero to 24 h postinfusion [AUC0-24]) in ELF was 20% to 31% of that in plasma for total drug after the third dose, and the relationship between plasma and ELF exposure was linear (r2=0.97, P=0.016).
UR - http://www.scopus.com/inward/record.url?scp=84898616625&partnerID=8YFLogxK
U2 - 10.1128/AAC.00053-14
DO - 10.1128/AAC.00053-14
M3 - Article
C2 - 24566183
AN - SCOPUS:84898616625
SN - 0066-4804
VL - 58
SP - 2964
EP - 2967
JO - Antimicrobial Agents and Chemotherapy
JF - Antimicrobial Agents and Chemotherapy
IS - 5
ER -