TY - GEN
T1 - Intravascular photoacoustic imaging of human coronary atherosclerosis
AU - Jansen, Krista
AU - Van Der Steen, Antonius F.W.
AU - Springeling, Geert
AU - Van Beusekom, Heleen M.M.
AU - Oosterhuis, J. Wolter
AU - Van Soest, Gijs
N1 - Funding Information:
The authors wish to thank E.W. Brascamp, E.A. Huisman and J.J. van der Poel for critically reading the manuscript. This research was supported by the Earth and Life Sciences Foundation (ALW project no. 805-33.102), which is subsidised by the Netherlands Organisation for Scientific Research (NWO).
PY - 2011
Y1 - 2011
N2 - We demonstrate intravascular photoacoustic imaging of human coronary atherosclerotic plaque. We specifically imaged lipid content, a key factor in vulnerable plaques that may lead to myocardial infarction. An integrated intravascular photoacoustics (IVPA) and ultrasound (IVUS) catheter with an outer diameter of 1.25 mm was developed. The catheter comprises an angle-polished optical fiber adjacent to a 30 MHz single-element transducer. The ultrasonic transducer was optically isolated to eliminate artifacts in the PA image. We performed measurements on a cylindrical vessel phantom and isolated point targets to demonstrate its imaging performance. Axial and lateral point spread function widths were 110 μm and 550 μm, respectively, for PA and 89 μm and 420 μm for US. We imaged two fresh human coronary arteries, showing different stages of disease, ex vivo. Specific photoacoustic imaging of lipid content, is achieved by spectroscopic imaging at different wavelengths between 1180 and 1230 nm.
AB - We demonstrate intravascular photoacoustic imaging of human coronary atherosclerotic plaque. We specifically imaged lipid content, a key factor in vulnerable plaques that may lead to myocardial infarction. An integrated intravascular photoacoustics (IVPA) and ultrasound (IVUS) catheter with an outer diameter of 1.25 mm was developed. The catheter comprises an angle-polished optical fiber adjacent to a 30 MHz single-element transducer. The ultrasonic transducer was optically isolated to eliminate artifacts in the PA image. We performed measurements on a cylindrical vessel phantom and isolated point targets to demonstrate its imaging performance. Axial and lateral point spread function widths were 110 μm and 550 μm, respectively, for PA and 89 μm and 420 μm for US. We imaged two fresh human coronary arteries, showing different stages of disease, ex vivo. Specific photoacoustic imaging of lipid content, is achieved by spectroscopic imaging at different wavelengths between 1180 and 1230 nm.
KW - Atherosclerosis
KW - Intravascular catheter
KW - Intravascular imaging
KW - Intravascular ultrasound
KW - Photoacoustics
KW - Spectroscopic imaging
KW - Tissue characterization
KW - Vulnerable plaque
UR - http://www.scopus.com/inward/record.url?scp=79955495096&partnerID=8YFLogxK
U2 - 10.1117/12.871382
DO - 10.1117/12.871382
M3 - Conference contribution
AN - SCOPUS:79955495096
SN - 9780819484369
T3 - Progress in Biomedical Optics and Imaging - Proceedings of SPIE
BT - Photons Plus Ultrasound
T2 - Photons Plus Ultrasound: Imaging and Sensing 2011
Y2 - 23 January 2011 through 25 January 2011
ER -