Invasive pulmonary aspergillosis associated with viral pneumonitis

Intan MW Dewi; Nico AF Janssen; Diletta Rosati; Mariolina Bruno; Mihai G. Netea; Roger JM Brüggemann; Paul E. Verweij; Frank L. van de Veerdonk

doi:10.1016/j.mib.2021.04.006

Invasive pulmonary aspergillosis associated with viral pneumonitis

Intan MW Dewi, Nico AF Janssen, Diletta Rosati, Mariolina Bruno, Mihai G. Netea, Roger JM Brüggemann, Paul E. Verweij, Frank L. van de Veerdonk

Onderzoeksoutput: Bijdrage aan tijdschrift › Artikel recenseren › peer review

41 Citaten (Scopus)

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The occurrence of invasive pulmonary aspergillosis (IPA) in critically ill patients with viral pneumonitis has increasingly been reported in recent years. Influenza-associated pulmonary aspergillosis (IAPA) and COVID-19-associated pulmonary aspergillosis (CAPA) are the two most common forms of this fungal infection. These diseases cause high mortality in patients, most of whom were previously immunocompetent. The pathogenesis of IAPA and CAPA is still not fully understood, but involves viral, fungal and host factors. In this article, we discuss several aspects regarding IAPA and CAPA, including their possible pathogenesis, the use of immunotherapy, and future challenges.

Originele taal-2	Engels
Pagina's (van-tot)	21-27
Aantal pagina's	7
Tijdschrift	Current Opinion in Microbiology
Volume	62
DOI's	https://doi.org/10.1016/j.mib.2021.04.006
Status	Gepubliceerd - aug. 2021
Extern gepubliceerd	Ja

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title = "Invasive pulmonary aspergillosis associated with viral pneumonitis",

abstract = "The occurrence of invasive pulmonary aspergillosis (IPA) in critically ill patients with viral pneumonitis has increasingly been reported in recent years. Influenza-associated pulmonary aspergillosis (IAPA) and COVID-19-associated pulmonary aspergillosis (CAPA) are the two most common forms of this fungal infection. These diseases cause high mortality in patients, most of whom were previously immunocompetent. The pathogenesis of IAPA and CAPA is still not fully understood, but involves viral, fungal and host factors. In this article, we discuss several aspects regarding IAPA and CAPA, including their possible pathogenesis, the use of immunotherapy, and future challenges.",

author = "Dewi, {Intan MW} and Janssen, {Nico AF} and Diletta Rosati and Mariolina Bruno and Netea, {Mihai G.} and Br{\"u}ggemann, {Roger JM} and Verweij, {Paul E.} and {van de Veerdonk}, {Frank L.}",

note = "Publisher Copyright: {\textcopyright} 2021 The Authors",

year = "2021",

month = aug,

doi = "10.1016/j.mib.2021.04.006",

language = "English",

volume = "62",

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T1 - Invasive pulmonary aspergillosis associated with viral pneumonitis

AU - Dewi, Intan MW

AU - Janssen, Nico AF

AU - Rosati, Diletta

AU - Bruno, Mariolina

AU - Netea, Mihai G.

AU - Brüggemann, Roger JM

AU - Verweij, Paul E.

AU - van de Veerdonk, Frank L.

PY - 2021/8

Y1 - 2021/8

N2 - The occurrence of invasive pulmonary aspergillosis (IPA) in critically ill patients with viral pneumonitis has increasingly been reported in recent years. Influenza-associated pulmonary aspergillosis (IAPA) and COVID-19-associated pulmonary aspergillosis (CAPA) are the two most common forms of this fungal infection. These diseases cause high mortality in patients, most of whom were previously immunocompetent. The pathogenesis of IAPA and CAPA is still not fully understood, but involves viral, fungal and host factors. In this article, we discuss several aspects regarding IAPA and CAPA, including their possible pathogenesis, the use of immunotherapy, and future challenges.

AB - The occurrence of invasive pulmonary aspergillosis (IPA) in critically ill patients with viral pneumonitis has increasingly been reported in recent years. Influenza-associated pulmonary aspergillosis (IAPA) and COVID-19-associated pulmonary aspergillosis (CAPA) are the two most common forms of this fungal infection. These diseases cause high mortality in patients, most of whom were previously immunocompetent. The pathogenesis of IAPA and CAPA is still not fully understood, but involves viral, fungal and host factors. In this article, we discuss several aspects regarding IAPA and CAPA, including their possible pathogenesis, the use of immunotherapy, and future challenges.

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U2 - 10.1016/j.mib.2021.04.006

DO - 10.1016/j.mib.2021.04.006

M3 - Review article

C2 - 34034082

AN - SCOPUS:85110588385

SN - 1369-5274

VL - 62

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EP - 27

JO - Current Opinion in Microbiology

JF - Current Opinion in Microbiology

ER -

Invasive pulmonary aspergillosis associated with viral pneumonitis

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