Irinotecan for relapsed Wilms tumor in pediatric patients: SIOP experience and review of the literature—A report from the SIOP Renal Tumor Study Group

Janna A. Hol; Marry M. van den Heuvel-Eibrink; Norbert Graf; Kathy Pritchard-Jones; Jesper Brok; Harm van Tinteren; Lisa Howell; Arnauld Verschuur; Christophe Bergeron; Leo Kager; Serena Catania; Filippo Spreafico; Annelies M.C. Mavinkurve-Groothuis

doi:10.1002/pbc.26849

Irinotecan for relapsed Wilms tumor in pediatric patients: SIOP experience and review of the literature—A report from the SIOP Renal Tumor Study Group

Janna A. Hol, Marry M. van den Heuvel-Eibrink, Norbert Graf, Kathy Pritchard-Jones, Jesper Brok, Harm van Tinteren, Lisa Howell, Arnauld Verschuur, Christophe Bergeron, Leo Kager, Serena Catania, Filippo Spreafico, Annelies M.C. Mavinkurve-Groothuis

Group van den Heuvel

Onderzoeksoutput: Bijdrage aan tijdschrift › Artikel › peer review

12 Citaten (Scopus)

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While irinotecan has been studied in various pediatric solid tumors, its potential role in Wilms tumor (WT) is less clear. We evaluated response and outcome of irinotecan-containing regimens in relapsed WT and compared our results to the available literature. Among 14 evaluable patients, one complete response (CR) and two partial responses (PRs) were observed in patients with initial intermediate-risk (CR and PR) and blastemal-type histologies (PR). Two patients were alive at last follow-up showing no evidence of disease. Our results and the reviewed literature suggest some effectiveness of irinotecan in the setting of relapsed WT.

Originele taal-2	Engels
Artikelnummer	e26849
Tijdschrift	Pediatric Blood and Cancer
Volume	65
Nummer van het tijdschrift	2
DOI's	https://doi.org/10.1002/pbc.26849
Status	Gepubliceerd - feb. 2018

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Hol, J. A., van den Heuvel-Eibrink, M. M., Graf, N., Pritchard-Jones, K., Brok, J., van Tinteren, H., Howell, L., Verschuur, A., Bergeron, C., Kager, L., Catania, S., Spreafico, F., & Mavinkurve-Groothuis, A. M. C. (2018). Irinotecan for relapsed Wilms tumor in pediatric patients: SIOP experience and review of the literature—A report from the SIOP Renal Tumor Study Group. Pediatric Blood and Cancer, 65(2), Artikel e26849. https://doi.org/10.1002/pbc.26849

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title = "Irinotecan for relapsed Wilms tumor in pediatric patients: SIOP experience and review of the literature—A report from the SIOP Renal Tumor Study Group",

abstract = "While irinotecan has been studied in various pediatric solid tumors, its potential role in Wilms tumor (WT) is less clear. We evaluated response and outcome of irinotecan-containing regimens in relapsed WT and compared our results to the available literature. Among 14 evaluable patients, one complete response (CR) and two partial responses (PRs) were observed in patients with initial intermediate-risk (CR and PR) and blastemal-type histologies (PR). Two patients were alive at last follow-up showing no evidence of disease. Our results and the reviewed literature suggest some effectiveness of irinotecan in the setting of relapsed WT.",

keywords = "irinotecan, pediatric solid tumors, relapsed Wilms tumor",

author = "Hol, {Janna A.} and {van den Heuvel-Eibrink}, {Marry M.} and Norbert Graf and Kathy Pritchard-Jones and Jesper Brok and {van Tinteren}, Harm and Lisa Howell and Arnauld Verschuur and Christophe Bergeron and Leo Kager and Serena Catania and Filippo Spreafico and Mavinkurve-Groothuis, {Annelies M.C.}",

note = "Publisher Copyright: {\textcopyright} 2017 Wiley Periodicals, Inc.",

year = "2018",

month = feb,

doi = "10.1002/pbc.26849",

language = "English",

volume = "65",

journal = "Pediatric Blood and Cancer",

issn = "1545-5009",

publisher = "Wiley-Liss Inc.",

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Hol, JA, van den Heuvel-Eibrink, MM, Graf, N, Pritchard-Jones, K, Brok, J, van Tinteren, H, Howell, L, Verschuur, A, Bergeron, C, Kager, L, Catania, S, Spreafico, F & Mavinkurve-Groothuis, AMC 2018, 'Irinotecan for relapsed Wilms tumor in pediatric patients: SIOP experience and review of the literature—A report from the SIOP Renal Tumor Study Group', Pediatric Blood and Cancer, vol. 65, nr. 2, e26849. https://doi.org/10.1002/pbc.26849

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T1 - Irinotecan for relapsed Wilms tumor in pediatric patients

T2 - SIOP experience and review of the literature—A report from the SIOP Renal Tumor Study Group

AU - Hol, Janna A.

AU - van den Heuvel-Eibrink, Marry M.

AU - Graf, Norbert

AU - Pritchard-Jones, Kathy

AU - Brok, Jesper

AU - van Tinteren, Harm

AU - Howell, Lisa

AU - Verschuur, Arnauld

AU - Bergeron, Christophe

AU - Kager, Leo

AU - Catania, Serena

AU - Spreafico, Filippo

AU - Mavinkurve-Groothuis, Annelies M.C.

PY - 2018/2

Y1 - 2018/2

N2 - While irinotecan has been studied in various pediatric solid tumors, its potential role in Wilms tumor (WT) is less clear. We evaluated response and outcome of irinotecan-containing regimens in relapsed WT and compared our results to the available literature. Among 14 evaluable patients, one complete response (CR) and two partial responses (PRs) were observed in patients with initial intermediate-risk (CR and PR) and blastemal-type histologies (PR). Two patients were alive at last follow-up showing no evidence of disease. Our results and the reviewed literature suggest some effectiveness of irinotecan in the setting of relapsed WT.

AB - While irinotecan has been studied in various pediatric solid tumors, its potential role in Wilms tumor (WT) is less clear. We evaluated response and outcome of irinotecan-containing regimens in relapsed WT and compared our results to the available literature. Among 14 evaluable patients, one complete response (CR) and two partial responses (PRs) were observed in patients with initial intermediate-risk (CR and PR) and blastemal-type histologies (PR). Two patients were alive at last follow-up showing no evidence of disease. Our results and the reviewed literature suggest some effectiveness of irinotecan in the setting of relapsed WT.

KW - irinotecan

KW - pediatric solid tumors

KW - relapsed Wilms tumor

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U2 - 10.1002/pbc.26849

DO - 10.1002/pbc.26849

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AN - SCOPUS:85038590813

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ER -

Irinotecan for relapsed Wilms tumor in pediatric patients: SIOP experience and review of the literature—A report from the SIOP Renal Tumor Study Group

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