KIAA1524: A novel MLL translocation partner in acute myeloid leukemia

Eva A. Coenen; C. Michel Zwaan; Claus Meyer; Rolf Marschalek; Rob Pieters; Lars T. van der Veken; H. Berna Beverloo; Marry M. Van den Heuvel-Eibrink

doi:10.1016/j.leukres.2010.08.017

KIAA1524: A novel MLL translocation partner in acute myeloid leukemia

Eva A. Coenen, C. Michel Zwaan, Claus Meyer, Rolf Marschalek, Rob Pieters, Lars T. van der Veken, H. Berna Beverloo, Marry M. Van den Heuvel-Eibrink

Onderzoeksoutput: Bijdrage aan tijdschrift › Artikel › peer review

22 Citaten (Scopus)

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The Mixed Lineage Leukemia gene on chromosome 11q23 is a frequent site of recurrent translocations in acute leukemias. Its promiscuous character is reflected by the more than 60 different translocation partners described in literature. Prompted by karyotype and atypical FISH results, we identified a new translocation partner in infant acute myeloid leukemia, KIAA1524 on 3q13.13, also known as 'Cancerous Inhibitor of Protein phosphatase 2A (CIP2A)'. This gene was recently identified as a proto-oncogene stabilizing MYC protein in gastric carcinoma. KIAA1524 has never been related to hematologic malignancies before, and the current AML case is the first case in which an MLL-KIAA1524 fusion was described.

Originele taal-2	Engels
Pagina's (van-tot)	133-135
Aantal pagina's	3
Tijdschrift	Leukemia Research
Volume	35
Nummer van het tijdschrift	1
DOI's	https://doi.org/10.1016/j.leukres.2010.08.017
Status	Gepubliceerd - jan. 2011
Extern gepubliceerd	Ja

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title = "KIAA1524: A novel MLL translocation partner in acute myeloid leukemia",

abstract = "The Mixed Lineage Leukemia gene on chromosome 11q23 is a frequent site of recurrent translocations in acute leukemias. Its promiscuous character is reflected by the more than 60 different translocation partners described in literature. Prompted by karyotype and atypical FISH results, we identified a new translocation partner in infant acute myeloid leukemia, KIAA1524 on 3q13.13, also known as 'Cancerous Inhibitor of Protein phosphatase 2A (CIP2A)'. This gene was recently identified as a proto-oncogene stabilizing MYC protein in gastric carcinoma. KIAA1524 has never been related to hematologic malignancies before, and the current AML case is the first case in which an MLL-KIAA1524 fusion was described.",

keywords = "Acute myeloid leukemia, CIP2A, KIAA1524, MLL",

author = "Coenen, {Eva A.} and Zwaan, {C. Michel} and Claus Meyer and Rolf Marschalek and Rob Pieters and {van der Veken}, {Lars T.} and Beverloo, {H. Berna} and {Van den Heuvel-Eibrink}, {Marry M.}",

note = "Funding Information: This work was supported by the Pediatric Oncology Foundation Rotterdam (KOCR). ",

year = "2011",

month = jan,

doi = "10.1016/j.leukres.2010.08.017",

language = "English",

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pages = "133--135",

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T2 - A novel MLL translocation partner in acute myeloid leukemia

AU - Coenen, Eva A.

AU - Zwaan, C. Michel

AU - Meyer, Claus

AU - Marschalek, Rolf

AU - Pieters, Rob

AU - van der Veken, Lars T.

AU - Beverloo, H. Berna

AU - Van den Heuvel-Eibrink, Marry M.

N1 - Funding Information: This work was supported by the Pediatric Oncology Foundation Rotterdam (KOCR).

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AB - The Mixed Lineage Leukemia gene on chromosome 11q23 is a frequent site of recurrent translocations in acute leukemias. Its promiscuous character is reflected by the more than 60 different translocation partners described in literature. Prompted by karyotype and atypical FISH results, we identified a new translocation partner in infant acute myeloid leukemia, KIAA1524 on 3q13.13, also known as 'Cancerous Inhibitor of Protein phosphatase 2A (CIP2A)'. This gene was recently identified as a proto-oncogene stabilizing MYC protein in gastric carcinoma. KIAA1524 has never been related to hematologic malignancies before, and the current AML case is the first case in which an MLL-KIAA1524 fusion was described.

KW - Acute myeloid leukemia

KW - CIP2A

KW - KIAA1524

KW - MLL

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U2 - 10.1016/j.leukres.2010.08.017

DO - 10.1016/j.leukres.2010.08.017

M3 - Article

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SN - 0145-2126

VL - 35

SP - 133

EP - 135

JO - Leukemia Research

JF - Leukemia Research

IS - 1

ER -

KIAA1524: A novel MLL translocation partner in acute myeloid leukemia

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