@article{e19a78078a5a437aa1f4d10a3ed167af,
title = "Lack of Bcl10 mutations in testicular germ cell tumours and derived cell lines",
abstract = "Aberrations within Bcl10, a gene involved in execution of apoptosis, has most recently been found in a variety of cancers, including cell lines of testicular germ cell tumours of adolescents and adults (TGCTs). To study this in more detail, we screened exons 2 and 3 of this gene for mutations in a larger series of cell lines as well as primary TGCTs by single-strand conformation polymorphism and endonuclease restriction analysis. Because no aberrations were detected, we conclude that inactivation of Bcl10 by mutation is at least far less important in the development of TGCTs than proposed.",
keywords = "Adaptor Proteins, Signal Transducing, Adolescent, Adult, B-Cell CLL-Lymphoma 10 Protein, Base Sequence, DNA, Neoplasm, Exons, Germinoma/genetics, Humans, Male, Molecular Sequence Data, Neoplasm Proteins/genetics, Polymorphism, Single-Stranded Conformational, Testicular Neoplasms/genetics, Tumor Cells, Cultured",
author = "{van Schothorst}, {E M} and S Mohkamsing and {van Gurp}, {R J} and Oosterhuis, {J W} and {van der Saag}, {P T} and Looijenga, {L H}",
note = "Funding Information: This project is financially supported by the Dutch Cancer Society (JWO and LL, and grant 97 1516 for EMvS and SM). We kindly thank Dr MA Versnel, Department of Immunology, Erasmus University Rotterdam, The Netherlands for providing the mesothelioma cell line.",
year = "1999",
month = jul,
doi = "10.1038/sj.bjc.6690563",
language = "English",
volume = "80",
pages = "1571--4",
journal = "British journal of cancer",
issn = "0007-0920",
publisher = "Nature Publishing Group",
number = "10",
}