Lack of Bcl10 mutations in testicular germ cell tumours and derived cell lines

E M van Schothorst, S Mohkamsing, R J van Gurp, J W Oosterhuis, P T van der Saag, L H Looijenga

Onderzoeksoutput: Bijdrage aan tijdschriftArtikelpeer review

Samenvatting

Aberrations within Bcl10, a gene involved in execution of apoptosis, has most recently been found in a variety of cancers, including cell lines of testicular germ cell tumours of adolescents and adults (TGCTs). To study this in more detail, we screened exons 2 and 3 of this gene for mutations in a larger series of cell lines as well as primary TGCTs by single-strand conformation polymorphism and endonuclease restriction analysis. Because no aberrations were detected, we conclude that inactivation of Bcl10 by mutation is at least far less important in the development of TGCTs than proposed.

Originele taal-2Engels
Pagina's (van-tot)1571-4
Aantal pagina's4
TijdschriftBritish journal of cancer
Volume80
Nummer van het tijdschrift10
DOI's
StatusGepubliceerd - jul. 1999
Extern gepubliceerdJa

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