Layer-specific diffusion weighted imaging in human primary visual cortex invitro

Michiel Kleinnijenhuis, Valerio Zerbi, Benno Küsters, Cornelis H. Slump, Markus Barth, Anne Marie van Cappellen van Walsum

Onderzoeksoutput: Bijdrage aan tijdschriftArtikelpeer review

50 Citaten (Scopus)

Samenvatting

One of the most prominent characteristics of the human neocortex is its laminated structure. The first person to observe this was Francesco Gennari in the second half the 18th century: in the middle of the depth of primary visual cortex, myelinated fibres are so abundant that he could observe them with bare eyes as a white line. Because of its saliency, the stria of Gennari has a rich history in cyto- and myeloarchitectural research as well as in magnetic resonance (MR) microscopy. In the present paper we show for the first time the layered structure of the human neocortex with exvivo diffusion weighted imaging (DWI). To achieve the necessary spatial and angular resolution, primary visual cortex samples were scanned on an 11.7T small-animal MR system to characterize the diffusion properties of the cortical laminae and the stria of Gennari in particular. The results demonstrated that fractional anisotropy varied over cortical depth, showing reduced anisotropy in the stria of Gennari, the inner band of Baillarger and the deepest layer of the cortex. Orientation density functions showed multiple components in the stria of Gennari and deeper layers of the cortex. Potential applications of layer-specific diffusion imaging include characterization of clinical abnormalities, cortical mapping and (intra)cortical tractography. We conclude that future high-resolution invivo cortical DWI investigations should take into account the layer-specificity of the diffusion properties.

Originele taal-2Engels
Pagina's (van-tot)2569-2582
Aantal pagina's14
TijdschriftCortex
Volume49
Nummer van het tijdschrift9
DOI's
StatusGepubliceerd - okt. 2013
Extern gepubliceerdJa

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