LEF1 turns over a new leaf

W. De Lau; H. Clevers

doi:10.1038/88233

LEF1 turns over a new leaf

W. De Lau, H. Clevers

Onderzoeksoutput: Bijdrage aan tijdschrift › Kort overzicht › peer review

13 Citaten (Scopus)

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LEF and TCF transcription factors (referred to collectively as LEF/TCFs) are pivotal players in the molecular pathology of cancer of the intestinal tract. Mutant components of the Wnt signal transduction cascade invariably lead to the inappropriate activation of LEF/TCFs in the cancer cell. A new study provides evidence for an unexpected amplification step in this cascade. The inappropriate activity of the Wnt pathway in colorectal cancer cells induces the expression of LEF1, which is normally not expressed in intestinal epithelium.

Originele taal-2	Engels
Pagina's (van-tot)	3-4
Aantal pagina's	2
Tijdschrift	Nature Genetics
Volume	28
Nummer van het tijdschrift	1
DOI's	https://doi.org/10.1038/88233
Status	Gepubliceerd - 2001
Extern gepubliceerd	Ja

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10.1038/88233

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LEF1 turns over a new leaf

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