Leukocytes Crossing the Endothelium: A Matter of Communication

Ilse Timmerman, Anna E. Daniel, Jeffrey Kroon, Jaap D. Van Buul

Onderzoeksoutput: Hoofdstuk in Boek/Rapport/CongresprocedureHoofdstukpeer review

33 Citaten (Scopus)


Leukocytes cross the endothelial vessel wall in a process called transendothelial migration (TEM). The purpose of leukocyte TEM is to clear the causing agents of inflammation in underlying tissues, for example, bacteria and viruses. During TEM, endothelial cells initiate signals that attract and guide leukocytes to sites of tissue damage. Leukocytes react by attaching to these sites and signal their readiness to move back to endothelial cells. Endothelial cells in turn respond by facilitating the passage of leukocytes while retaining overall integrity. In this review, we present recent findings in the field and we have endeavored to synthesize a coherent picture of the intricate interplay between endothelial cells and leukocytes during TEM.

Originele taal-2Engels
TitelInternational Review of Cell and Molecular Biology
UitgeverijElsevier Inc.
Aantal pagina's49
StatusGepubliceerd - 2016
Extern gepubliceerdJa

Publicatie series

NaamInternational Review of Cell and Molecular Biology
ISSN van geprinte versie1937-6448


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