TY - JOUR
T1 - Lgr6 marks stem cells in the hair follicle that generate all cell lineages of the skin
AU - Snippert, Hugo J.
AU - Haegebarth, Andrea
AU - Kasper, Maria
AU - Jaks, Viljar
AU - Van Es, Johan H.
AU - Barker, Nick
AU - Van De Wetering, Marc
AU - Van Den Born, Maaike
AU - Begthel, Harry
AU - Vries, Robert G.
AU - Stange, Daniel E.
AU - Toftgård, Rune
AU - Clevers, Hans
PY - 2010/3/12
Y1 - 2010/3/12
N2 - Mammalian epidermis consists of three self-renewing compartments: the hair follicle, the sebaceous gland, and the interfollicuLar epidermis. We generated knock-in alleles of murine Lgr6, a close relative of the Lgr5 stem cell gene. Lgr6 was expressed in the earliest embryonic hair placodes. In adult hair follicles, Lgr6+ cells resided in a previously uncharacterized region directly above the follicle bulge. They expressed none of the known bulge stem cell markers. Prenatal Lgr6+ cells established the hair follicle, sebaceous gland, and interfollicuLar epidermis. Postnatally, Lgr6+ cells generated sebaceous gland and interfollicular epidermis, whereas contribution to hair lineages gradually diminished with age. Adult Lgr6+ cells executed long-term wound repair, including the formation of new hair follicles. We conclude that Lgr6 marks the most primitive epidermal stem cell.
AB - Mammalian epidermis consists of three self-renewing compartments: the hair follicle, the sebaceous gland, and the interfollicuLar epidermis. We generated knock-in alleles of murine Lgr6, a close relative of the Lgr5 stem cell gene. Lgr6 was expressed in the earliest embryonic hair placodes. In adult hair follicles, Lgr6+ cells resided in a previously uncharacterized region directly above the follicle bulge. They expressed none of the known bulge stem cell markers. Prenatal Lgr6+ cells established the hair follicle, sebaceous gland, and interfollicuLar epidermis. Postnatally, Lgr6+ cells generated sebaceous gland and interfollicular epidermis, whereas contribution to hair lineages gradually diminished with age. Adult Lgr6+ cells executed long-term wound repair, including the formation of new hair follicles. We conclude that Lgr6 marks the most primitive epidermal stem cell.
UR - http://www.scopus.com/inward/record.url?scp=77949360959&partnerID=8YFLogxK
U2 - 10.1126/science.1184733
DO - 10.1126/science.1184733
M3 - Article
C2 - 20223988
AN - SCOPUS:77949360959
SN - 0036-8075
VL - 327
SP - 1385
EP - 1389
JO - Science
JF - Science
IS - 5971
ER -