Liquid chromatography-tandem mass spectrometric assay for the PI3K/mTOR inhibitor GSK2126458 in mouse plasma and tumor homogenate

Keyphrases

• Acetonitrile 33%
• Analytical Condition 33%
• Bioanalytics 33%
• Chromatographic System 33%
• Dabrafenib 33%
• Drug Levels 33%
• Electrospray Interface 33%
• Eluate 33%
• GSK2126458 100%
• Liquid Chromatographic 33%
• Liquid Chromatography-tandem Mass 100%
• Liquid Chromatography-tandem Mass Spectrometry (LC-MS/MS) 33%
• Logarithmic Calibration 33%
• Mass Spectrometry 100%
• Monitoring Mode 33%
• Mouse Plasma 100%
• Mouse Tumor 100%
• Neuroblastoma 33%
• Oral Administration 33%
• PI3K-mTOR Inhibitors 100%
• Protein Precipitation 33%
• Reversed Phase 33%
• Selected Reaction Monitoring 33%
• Spectrometric Assay 100%
• Triple Quadrupole Mass Spectrometer 33%
• Tumor Drugs 33%
• Tumor Homogenate 100%
• Xenograft 33%

Chemistry

• Acetonitrile 50%
• Dabrafenib 50%
• Dilution 50%
• Electrospray 50%
• Liquid Chromatography 100%
• Liquid Chromatography Mass Spectrometry 50%
• Mammalian Target of Rapamycin Inhibitor 100%
• Protein Precipitation 50%
• Quadrupole 50%
• Tandem Mass Spectrometry 50%