Live and let die in the intestinal epithelium

Elena Sancho, Eduard Batlle, Hans Clevers

Onderzoeksoutput: Bijdrage aan tijdschriftArtikel recenserenpeer review

180 Citaten (Scopus)


The intestinal epithelium is a relatively simple developmental system and a prime example of tissue renewal from a source of multipotent stem cells. Throughout adulthood, intestinal epithelial proliferation, cell-fate specification and differentiation are coupled to migration in discrete units known as crypts of Lieberkühn. Physically guided by Eph receptors and their ligands, the ephrins, stem cell progeny transit through the proliferation/differentiation switch, and Notch diversifies their subsequent fates. Wnt signalling appears to control most of these events.

Originele taal-2Engels
Pagina's (van-tot)763-770
Aantal pagina's8
TijdschriftCurrent Opinion in Cell Biology
Nummer van het tijdschrift6
StatusGepubliceerd - dec. 2003
Extern gepubliceerdJa


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