Localization of the nucleotide excision repair gene ERCC6 to human chromosome 10q11-q21

C. Troelstra; R. M. Landsvater; J. Wiegant; M. van der Ploeg; G. Viel; C. H.C.M. Buys; J. H.J. Hoeijmakers

doi:10.1016/0888-7543(92)90304-B

Localization of the nucleotide excision repair gene ERCC6 to human chromosome 10q11-q21

C. Troelstra, R. M. Landsvater, J. Wiegant, M. van der Ploeg, G. Viel, C. H.C.M. Buys, J. H.J. Hoeijmakers

Onderzoeksoutput: Bijdrage aan tijdschrift › Artikel › peer review

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We have cloned the human DNA excision repair gene ERCC6 by virtue of its ability to correct the uv sensitivity of Chinese hamster ovary cell mutant UV61. This mutant is a member of complementation group 6 of the nucleotide excision repair-deficient rodent mutants. By means of in situ hybridization and Southern blot analysis of mouse × human somatic cell hybrids, the gene was localized to human chromosome 10q11-q21. An RFLP detected within the ERCC6 locus can be helpful in linkage analysis.

Originele taal-2	Engels
Pagina's (van-tot)	745-749
Aantal pagina's	5
Tijdschrift	Genomics
Volume	12
Nummer van het tijdschrift	4
DOI's	https://doi.org/10.1016/0888-7543(92)90304-B
Status	Gepubliceerd - apr. 1992
Extern gepubliceerd	Ja

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title = "Localization of the nucleotide excision repair gene ERCC6 to human chromosome 10q11-q21",

abstract = "We have cloned the human DNA excision repair gene ERCC6 by virtue of its ability to correct the uv sensitivity of Chinese hamster ovary cell mutant UV61. This mutant is a member of complementation group 6 of the nucleotide excision repair-deficient rodent mutants. By means of in situ hybridization and Southern blot analysis of mouse × human somatic cell hybrids, the gene was localized to human chromosome 10q11-q21. An RFLP detected within the ERCC6 locus can be helpful in linkage analysis.",

author = "C. Troelstra and Landsvater, {R. M.} and J. Wiegant and {van der Ploeg}, M. and G. Viel and Buys, {C. H.C.M.} and Hoeijmakers, {J. H.J.}",

note = "Funding Information: We are grateful to Dr. D. Bootsma for helpful suggestions and critical reading of the manuscript. We thank M. Kuit for photography. This study was supported in part (R.M.L., G.V., and C.H.C.M.B.) the Dutch Prevention Fund.",

year = "1992",

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doi = "10.1016/0888-7543(92)90304-B",

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T1 - Localization of the nucleotide excision repair gene ERCC6 to human chromosome 10q11-q21

AU - Troelstra, C.

AU - Landsvater, R. M.

AU - Wiegant, J.

AU - van der Ploeg, M.

AU - Viel, G.

AU - Buys, C. H.C.M.

AU - Hoeijmakers, J. H.J.

N1 - Funding Information: We are grateful to Dr. D. Bootsma for helpful suggestions and critical reading of the manuscript. We thank M. Kuit for photography. This study was supported in part (R.M.L., G.V., and C.H.C.M.B.) the Dutch Prevention Fund.

PY - 1992/4

Y1 - 1992/4

N2 - We have cloned the human DNA excision repair gene ERCC6 by virtue of its ability to correct the uv sensitivity of Chinese hamster ovary cell mutant UV61. This mutant is a member of complementation group 6 of the nucleotide excision repair-deficient rodent mutants. By means of in situ hybridization and Southern blot analysis of mouse × human somatic cell hybrids, the gene was localized to human chromosome 10q11-q21. An RFLP detected within the ERCC6 locus can be helpful in linkage analysis.

AB - We have cloned the human DNA excision repair gene ERCC6 by virtue of its ability to correct the uv sensitivity of Chinese hamster ovary cell mutant UV61. This mutant is a member of complementation group 6 of the nucleotide excision repair-deficient rodent mutants. By means of in situ hybridization and Southern blot analysis of mouse × human somatic cell hybrids, the gene was localized to human chromosome 10q11-q21. An RFLP detected within the ERCC6 locus can be helpful in linkage analysis.

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Localization of the nucleotide excision repair gene ERCC6 to human chromosome 10q11-q21

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