Long-term effects of growth hormone therapy on bone mineral density, body composition, and serum lipid levels in growth hormone deficient children: A 6-year follow-up study

Inge M. Van Der Sluis, Annemieke M. Boot, Wim C. Hop, Yolanda B. De Rijke, Eric P. Krenning, Sabine M.P.F. De Muinck Keizer-Schrama

Onderzoeksoutput: Bijdrage aan tijdschriftArtikelpeer review

76 Citaten (Scopus)

Samenvatting

Aim: To study the effects of growth hormone (GH) deficiency (GHD) and GH replacement therapy (GHRx) on bone mineral density (BMD) and body composition. Methods: 59 GHD children participated (age range 0.4-16.9 years); the follow-up period was 6 years. Lumbar spine BMD (BMDLS), total-body BMD (BMDTB), and body composition were measured prospectively using dual-energy X-ray absorptiometry. Results: Mean BMDLS and BMDTB were significantly reduced at the time of the diagnosis. The bone mineral apparent density of the lumbar spine (BMADLS) was reduced to a lesser degree. The BMADLS increased to normal values after 1 year; BMDLS and BMDTB normalized 1 year later. At the time of the diagnosis, the lean body mass was reduced and steadily increased during GHRx. Percentage of body fat was increased at baseline and normalized within 6 months. The severity of GHD was not associated with the BMD at diagnosis or the response to GHRx. Conclusion: Areal BMDLS and BMDTB and, to a lesser extent, BMADLS are decreased in GHD children, but normalize within 1-2 years.

Originele taal-2Engels
Pagina's (van-tot)207-214
Aantal pagina's8
TijdschriftHormone Research
Volume58
Nummer van het tijdschrift5
DOI's
StatusGepubliceerd - 2002
Extern gepubliceerdJa

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