Long-term nephrotoxicity in irradiated pediatric kidney tumor survivors: A systematic review

Raquel Dávila Fajardo; Paulien Raymakers-Janssen; Martine van Grotel; Roelie M van Wösten-van Asperen; Christianus H Terhaard; Marc R Lilien; Marry M van den Heuvel-Eibrink; Geert O Janssens

doi:10.1002/pbc.30624

Long-term nephrotoxicity in irradiated pediatric kidney tumor survivors: A systematic review

Raquel Dávila Fajardo, Paulien Raymakers-Janssen, Martine van Grotel, Roelie M van Wösten-van Asperen, Christianus H Terhaard, Marc R Lilien, Marry M van den Heuvel-Eibrink, Geert O Janssens

Group van den Heuvel

Onderzoeksoutput: Bijdrage aan tijdschrift › Artikel recenseren › peer review

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OBJECTIVE: Nephrotoxicity can occur as a side effect after treatment for kidney tumor in childhood. The use of radiotherapy (RT) has a potential additional effect.

METHODS: A systematic electronic literature search that combined childhood kidney cancer with different treatments and nephrotoxicity terms was performed in EMBASE. Studies were included based on the reporting of nephrotoxicity occurrence after treatment for kidney tumor during pediatric age, with 75% of participants being under the age of 25 years at the time of diagnosis, and having been treated with any type of kidney surgery, chemotherapy, and/or RT.

RESULTS: A pooled analysis did not show significant difference in estimated glomerular filtration rate between the group of patients who received RT compared with the group treated without RT (SMD -0.11 [95% CI -1.07-0.84] p = .733).

CONCLUSION: The current literature suggests that the use of RT does not have a significant impact on the decline of kidney function as independent factor.

Originele taal-2	Engels
Pagina's (van-tot)	e30624
Tijdschrift	Pediatric blood & cancer
Volume	70
Nummer van het tijdschrift	11
DOI's	https://doi.org/10.1002/pbc.30624
Status	Gepubliceerd - 2023

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10.1002/pbc.30624

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@article{b9eeecd25e4d452fb78995445dbfaedc,

title = "Long-term nephrotoxicity in irradiated pediatric kidney tumor survivors: A systematic review",

abstract = "OBJECTIVE: Nephrotoxicity can occur as a side effect after treatment for kidney tumor in childhood. The use of radiotherapy (RT) has a potential additional effect.METHODS: A systematic electronic literature search that combined childhood kidney cancer with different treatments and nephrotoxicity terms was performed in EMBASE. Studies were included based on the reporting of nephrotoxicity occurrence after treatment for kidney tumor during pediatric age, with 75% of participants being under the age of 25 years at the time of diagnosis, and having been treated with any type of kidney surgery, chemotherapy, and/or RT.RESULTS: A pooled analysis did not show significant difference in estimated glomerular filtration rate between the group of patients who received RT compared with the group treated without RT (SMD -0.11 [95% CI -1.07-0.84] p = .733).CONCLUSION: The current literature suggests that the use of RT does not have a significant impact on the decline of kidney function as independent factor.",

keywords = "Humans, Child, Adult, Kidney, Kidney Neoplasms/therapy, Survivors, Glomerular Filtration Rate",

author = "{D{\'a}vila Fajardo}, Raquel and Paulien Raymakers-Janssen and {van Grotel}, Martine and {van W{\"o}sten-van Asperen}, {Roelie M} and Terhaard, {Christianus H} and Lilien, {Marc R} and {van den Heuvel-Eibrink}, {Marry M} and Janssens, {Geert O}",

note = "{\textcopyright} 2023 The Authors. Pediatric Blood & Cancer published by Wiley Periodicals LLC.",

year = "2023",

doi = "10.1002/pbc.30624",

language = "English",

volume = "70",

pages = "e30624",

journal = "Pediatric blood & cancer",

issn = "1545-5009",

publisher = "Wiley-Liss Inc.",

number = "11",

}

TY - JOUR

T1 - Long-term nephrotoxicity in irradiated pediatric kidney tumor survivors

T2 - A systematic review

AU - Dávila Fajardo, Raquel

AU - Raymakers-Janssen, Paulien

AU - van Grotel, Martine

AU - van Wösten-van Asperen, Roelie M

AU - Terhaard, Christianus H

AU - Lilien, Marc R

AU - van den Heuvel-Eibrink, Marry M

AU - Janssens, Geert O

PY - 2023

Y1 - 2023

N2 - OBJECTIVE: Nephrotoxicity can occur as a side effect after treatment for kidney tumor in childhood. The use of radiotherapy (RT) has a potential additional effect.METHODS: A systematic electronic literature search that combined childhood kidney cancer with different treatments and nephrotoxicity terms was performed in EMBASE. Studies were included based on the reporting of nephrotoxicity occurrence after treatment for kidney tumor during pediatric age, with 75% of participants being under the age of 25 years at the time of diagnosis, and having been treated with any type of kidney surgery, chemotherapy, and/or RT.RESULTS: A pooled analysis did not show significant difference in estimated glomerular filtration rate between the group of patients who received RT compared with the group treated without RT (SMD -0.11 [95% CI -1.07-0.84] p = .733).CONCLUSION: The current literature suggests that the use of RT does not have a significant impact on the decline of kidney function as independent factor.

AB - OBJECTIVE: Nephrotoxicity can occur as a side effect after treatment for kidney tumor in childhood. The use of radiotherapy (RT) has a potential additional effect.METHODS: A systematic electronic literature search that combined childhood kidney cancer with different treatments and nephrotoxicity terms was performed in EMBASE. Studies were included based on the reporting of nephrotoxicity occurrence after treatment for kidney tumor during pediatric age, with 75% of participants being under the age of 25 years at the time of diagnosis, and having been treated with any type of kidney surgery, chemotherapy, and/or RT.RESULTS: A pooled analysis did not show significant difference in estimated glomerular filtration rate between the group of patients who received RT compared with the group treated without RT (SMD -0.11 [95% CI -1.07-0.84] p = .733).CONCLUSION: The current literature suggests that the use of RT does not have a significant impact on the decline of kidney function as independent factor.

KW - Humans

KW - Child

KW - Adult

KW - Kidney

KW - Kidney Neoplasms/therapy

KW - Survivors

KW - Glomerular Filtration Rate

U2 - 10.1002/pbc.30624

DO - 10.1002/pbc.30624

M3 - Review article

C2 - 37561390

SN - 1545-5009

VL - 70

SP - e30624

JO - Pediatric blood & cancer

JF - Pediatric blood & cancer

IS - 11

ER -

Long-term nephrotoxicity in irradiated pediatric kidney tumor survivors: A systematic review

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