Lymphomas with testicular localisation show a consistent BCL-2 expression without a translocation (14;18): a molecular and immunohistochemical study

A C Lambrechts, L H Looijenga, M B van't Veer, J van Echten, W Timens, J W Oosterhuis

Onderzoeksoutput: Bijdrage aan tijdschriftArtikelpeer review

Samenvatting

The presence of the BCL-2 protein was studied in nine non-Hodgkin's lymphomas with testicular localisation. A consistent presence of the BCL-2 protein was found. The chromosomal translocation (14;18) was seen neither by cytogenetic analysis (n = 4) nor by polymerase chain reaction amplification and Southern blotting (n = 9). Therefore, this translocation is not responsible for the presence of the BCL-2 protein in non-Hodgkin's lymphomas with testicular localisation. We suggest that the presence of the BCL-2 protein in these lymphomas is related to the differentiation stage of the B-lymphocytes or may play a role in the pathogenesis of these lymphomas. The consistent finding of the BCL-2 protein in lymphomas with testicular localisation may support the clinical observation that these lymphomas are a separate entity.

Originele taal-2Engels
Pagina's (van-tot)73-7
Aantal pagina's5
TijdschriftBritish journal of cancer
Volume71
Nummer van het tijdschrift1
DOI's
StatusGepubliceerd - jan. 1995
Extern gepubliceerdJa

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