TY - JOUR
T1 - Malignant melanoma as second malignant neoplasm in long-term childhood cancer survivors
T2 - A systematic review
AU - Braam, Katja I.
AU - Overbeek, Annelies
AU - Kaspers, Gertjan J.L.
AU - Ronckers, Cecile M.
AU - Schouten-van Meeteren, Annette Y.N.
AU - Van Dulmen-Den Broeder, Eline
AU - Veening, Margreet A.
PY - 2012/5
Y1 - 2012/5
N2 - This systematic review provides information on malignant melanoma as second malignant neoplasm (SMN) after childhood cancer and evaluates its risk factors. Study reports describing incidences of SMN and malignant melanoma as SMN in a population of childhood cancer survivors (CCS) were included. Of 151,575 CCS, 4,010 (2.6%) children developed an SMN, 212 of which were melanoma (5.3% or 0.14% of all CCS). The following risk factors for malignant melanoma as SMN were identified: radiotherapy, or the combination alkylating agents and anti-mitotic drugs. Melanomas are most frequently observed after Hodgkin disease, hereditary retinoblastoma, soft tissue sarcoma, and gonadal tumors.
AB - This systematic review provides information on malignant melanoma as second malignant neoplasm (SMN) after childhood cancer and evaluates its risk factors. Study reports describing incidences of SMN and malignant melanoma as SMN in a population of childhood cancer survivors (CCS) were included. Of 151,575 CCS, 4,010 (2.6%) children developed an SMN, 212 of which were melanoma (5.3% or 0.14% of all CCS). The following risk factors for malignant melanoma as SMN were identified: radiotherapy, or the combination alkylating agents and anti-mitotic drugs. Melanomas are most frequently observed after Hodgkin disease, hereditary retinoblastoma, soft tissue sarcoma, and gonadal tumors.
KW - Childhood cancer
KW - Childhood cancer survivor
KW - Melanoma
KW - Second malignant neoplasm
UR - http://www.scopus.com/inward/record.url?scp=84857821986&partnerID=8YFLogxK
U2 - 10.1002/pbc.24023
DO - 10.1002/pbc.24023
M3 - Review article
C2 - 22232079
AN - SCOPUS:84857821986
SN - 1545-5009
VL - 58
SP - 665
EP - 674
JO - Pediatric Blood and Cancer
JF - Pediatric Blood and Cancer
IS - 5
ER -