Malignant melanoma as second malignant neoplasm in long-term childhood cancer survivors: A systematic review

Katja I. Braam, Annelies Overbeek, Gertjan J.L. Kaspers, Cecile M. Ronckers, Annette Y.N. Schouten-van Meeteren, Eline Van Dulmen-Den Broeder, Margreet A. Veening

Onderzoeksoutput: Bijdrage aan tijdschriftArtikel recenserenpeer review

29 Citaten (Scopus)

Samenvatting

This systematic review provides information on malignant melanoma as second malignant neoplasm (SMN) after childhood cancer and evaluates its risk factors. Study reports describing incidences of SMN and malignant melanoma as SMN in a population of childhood cancer survivors (CCS) were included. Of 151,575 CCS, 4,010 (2.6%) children developed an SMN, 212 of which were melanoma (5.3% or 0.14% of all CCS). The following risk factors for malignant melanoma as SMN were identified: radiotherapy, or the combination alkylating agents and anti-mitotic drugs. Melanomas are most frequently observed after Hodgkin disease, hereditary retinoblastoma, soft tissue sarcoma, and gonadal tumors.

Originele taal-2Engels
Pagina's (van-tot)665-674
Aantal pagina's10
TijdschriftPediatric Blood and Cancer
Volume58
Nummer van het tijdschrift5
DOI's
StatusGepubliceerd - mei 2012
Extern gepubliceerdJa

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