Malignant transformation in sacrococcygeal teratoma and in presacral teratoma associated with Currarino syndrome: a comparative study

Marc Dirix, Tine van Becelaere, Lizanne Berkenbosch, Robertine van Baren, Rene M Wijnen, Marc H Wijnen, David C van der Zee, Hugo A Heij, Joep P M Derikx, L W Ernest van Heurn

Onderzoeksoutput: Bijdrage aan tijdschriftArtikelpeer review

40 Citaten (Scopus)

Samenvatting

BACKGROUND/PURPOSE: The risk of malignant transformation of sacrococcygeal teratoma (SCT) and of presacral teratoma in Currarino syndrome (CS) may differ despite the similar position and appearance.

METHODS: Malignant transformation and teratoma recurrence were assessed in a national retrospective comparative analysis of 205 SCT and 16 CS patients treated in one of the six pediatric surgical centers in the Netherlands between January 1981 and December 2010.

RESULTS: The malignancy free survival of patients with SCT was lower than for patients with a presacral teratoma associated with CS (80% and 58% after one and two years in SCT versus 100% after two years in CS, p=0.017) CONCLUSIONS: In SCT, malignancy and recurrence risk are high. Therefore, early and complete resection is mandatory. Our data show that the risk of malignant transformation of a presacral teratoma in CS is small.

Originele taal-2Engels
Pagina's (van-tot)462-4
Aantal pagina's3
TijdschriftJournal of Pediatric Surgery
Volume50
Nummer van het tijdschrift3
DOI's
StatusGepubliceerd - aug. 2014
Extern gepubliceerdJa

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