J. W. Oosterhuis, J. Marrink, B. De Jong, L. H.J. Looijenga, A. Geurts van Kessel

Onderzoeksoutput: Bijdrage aan tijdschriftKort overzichtpeer review


Among solid tumors, testicular germ cell tumors have served as role models in the development and application of tumor markers. The routinely measured 'specific' serum markers: human chorionic gonadotrophin (HCG; trophoblastic elements), alpha fetoprotein (AFP; yolk sac tumor) and placental like alkaline phosphatase (in particular seminoma) can be demonstrated immunohistochemically as well. TRA-1-60 is a new serum tumor marker, which in the context of germ cell tumors is specific for embryonal carcinoma, and is elevated in 60-70% of the cases with normal levels of AFP and HCG. The serum levels lactate dehydrogenase-1 (LDH-1), a marker for seminoma and nonseminoma, is correlated with the number of copies of the short arm of chromosome 12, and thus with the dose of the gene coding for this enzyme, which maps on 12p. Eighty percent of testicular germ cell tumors have one or more copies of a specific chromosomal marker: isochromosome 12p, composed of two short arms and the centromeric region of chromosome 12. Numerical and structural abnormalities of chromosome 12, among which i(12p), seem to be important in the genesis of germ cell tumors. Specific DNA sequences in the breakpoints in chromosome 12, when isolated, could play an important role in 'molecular staging' of testicular germ cell tumors.

Vertaalde titel van de bijdrageMarkers of testicular germ cell tumors
Originele taal-2Nederlands
Pagina's (van-tot)153-158
Aantal pagina's6
TijdschriftTijdschrift van de Nederlandse Vereniging voor Klinische Chemie
Nummer van het tijdschrift4
StatusGepubliceerd - 1991
Extern gepubliceerdJa


Duik in de onderzoeksthema's van 'MARKERS VAN KIEMCELTUMOREN VAN DE TESTIS'. Samen vormen ze een unieke vingerafdruk.

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