Mechanoregulation of cytoskeletal dynamics by TRP channels

Arthur J Kuipers, Jeroen Middelbeek, Frank N van Leeuwen

Onderzoeksoutput: Bijdrage aan tijdschriftArtikel recenserenpeer review

Samenvatting

The ability of cells to respond to mechanical stimulation is crucial to a variety of biological processes, including cell migration, axonal outgrowth, perception of pain, cardiovascular responses and kidney physiology. The translation of mechanical cues into cellular responses, a process known as mechanotransduction, typically takes place in specialized multiprotein structures such as cilia, cell-cell or cell-matrix adhesions. Within these structures, mechanical forces such as shear stress and membrane stretch activate mechanosensitive proteins, which set off a series of events that lead to altered cell behavior. Members of the transient receptor potential (TRP) family of cation channels are emerging as important players in mechanotransductory pathways. Localized within mechanosensory structures, they are activated by mechanical stimuli and trigger fast as well as sustained cytoskeletal responses. In this review, we will provide an overview of how TRP channels affect cytoskeletal dynamics in various mechano-regulated processes.

Originele taal-2Engels
Pagina's (van-tot)834-46
Aantal pagina's13
TijdschriftEuropean journal of cell biology
Volume91
Nummer van het tijdschrift11-12
DOI's
StatusGepubliceerd - 26 jun. 2012
Extern gepubliceerdJa

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