@article{efc1b2a7101042dba94e0d1e961192a7,
title = "Menadione inhibits MIBG uptake in two neuroendocrine cell lines",
abstract = "In this paper we report on our studies of the effect of menadione on the uptake of MIBG in the neuroendocrine cell lines PC12 and SIC-N-SH. Menadione inhibits the uptake of MIBG in both cell lines in a dose-dependent manner. Inhibition of MIBG uptake is most pronounced in the PC12 cell line. Comparison of the inhibitory action of menadione on the uptake and retention of MIBG with that of imipramine and reserpine suggests that menadione inhibits uptake 1 mediated uptake as well as granular storage.",
keywords = "Menadione, Meta-iodobenzylguanidine, Neuroblastoma, Oxidative stress, Uptake",
author = "J. Cornelissen and Tytgat, {G. A.M.} and {Van Den Brug}, M. and {Van Kuilenburg}, {A. B.P.} and Vo{\^u}te, {P. A.} and {Van Gennip}, {A. H.}",
note = "Funding Information: Paul Jonkergouw (Department of Safety, Health and Welfare, Nederlands Kanker Instituut) is thanked for preparing the [125I] MIBG. We would like to thank SJ and J Cook for critically reading of the manuscript. This study was supported by grant no. 92–03 from the {\textquoteleft}Stichting Kindergeneeskundig Kankeronderzoek{\textquoteright} (Foundation for Pediatric Cancer Research).",
year = "1997",
doi = "10.1023/A:1005718421774",
language = "English",
volume = "31",
pages = "147--151",
journal = "Journal of Neuro-Oncology",
issn = "0167-594X",
publisher = "Kluwer Academic Publishers",
number = "1-2",
}