Mining the Wnt pathway for cancer therapeutics

Nick Barker; Hans Clevers

doi:10.1038/nrd2154

Mining the Wnt pathway for cancer therapeutics

Nick Barker, Hans Clevers

Onderzoeksoutput: Bijdrage aan tijdschrift › Artikel recenseren › peer review

647 Citaten (Scopus)

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Aberrant activation of the Wnt pathway is implicated in driving the formation of various human cancers, particularly those of the digestive tract. Inhibition of aberrant Wnt pathway activity in cancer cell lines efficiently blocks their growth, highlighting the great potential of therapeutics designed to achieve this in cancer patients. Here we provide an overview of the promise and pitfalls of current drug development strategies striving to inhibit the Wnt pathway and present new opportunities for therapeutic intervention.

Originele taal-2	Engels
Pagina's (van-tot)	997-1014
Aantal pagina's	18
Tijdschrift	Nature Reviews Drug Discovery
Volume	5
Nummer van het tijdschrift	12
DOI's	https://doi.org/10.1038/nrd2154
Status	Gepubliceerd - dec. 2006
Extern gepubliceerd	Ja

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10.1038/nrd2154

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title = "Mining the Wnt pathway for cancer therapeutics",

abstract = "Aberrant activation of the Wnt pathway is implicated in driving the formation of various human cancers, particularly those of the digestive tract. Inhibition of aberrant Wnt pathway activity in cancer cell lines efficiently blocks their growth, highlighting the great potential of therapeutics designed to achieve this in cancer patients. Here we provide an overview of the promise and pitfalls of current drug development strategies striving to inhibit the Wnt pathway and present new opportunities for therapeutic intervention.",

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Mining the Wnt pathway for cancer therapeutics

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