Model organoids provide new research opportunities for ductal pancreatic cancer

Sylvia F. Boj; Chang Il Hwang; Lindsey A. Baker; Dannielle D. Engle; David A. Tuveson; Hans Clevers

doi:10.1080/23723556.2015.1014757

Model organoids provide new research opportunities for ductal pancreatic cancer

Sylvia F. Boj, Chang Il Hwang, Lindsey A. Baker, Dannielle D. Engle, David A. Tuveson, Hans Clevers

Onderzoeksoutput: Bijdrage aan tijdschrift › Artikel › peer review

53 Citaten (Scopus)

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We recently established organoid models from normal and neoplastic murine and human pancreas tissues. These organoids exhibit ductal- and disease stage-specific characteristics and, after orthotopic transplantation, recapitulate the full spectrum of tumor progression. Pancreatic organoid technology provides a novel platform for the study of tumor biology and the discovery of potential biomarkers, therapeutics, and personalized medicine strategies.

Originele taal-2	Engels
Artikelnummer	e1014757
Tijdschrift	Molecular and Cellular Oncology
Volume	3
Nummer van het tijdschrift	1
DOI's	https://doi.org/10.1080/23723556.2015.1014757
Status	Gepubliceerd - 2 jan. 2016
Extern gepubliceerd	Ja

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title = "Model organoids provide new research opportunities for ductal pancreatic cancer",

abstract = "We recently established organoid models from normal and neoplastic murine and human pancreas tissues. These organoids exhibit ductal- and disease stage-specific characteristics and, after orthotopic transplantation, recapitulate the full spectrum of tumor progression. Pancreatic organoid technology provides a novel platform for the study of tumor biology and the discovery of potential biomarkers, therapeutics, and personalized medicine strategies.",

keywords = "cancer, organoids, pancreatic ductal adenocarcinoma, preclinical models",

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doi = "10.1080/23723556.2015.1014757",

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AU - Hwang, Chang Il

AU - Baker, Lindsey A.

AU - Engle, Dannielle D.

AU - Tuveson, David A.

AU - Clevers, Hans

PY - 2016/1/2

Y1 - 2016/1/2

N2 - We recently established organoid models from normal and neoplastic murine and human pancreas tissues. These organoids exhibit ductal- and disease stage-specific characteristics and, after orthotopic transplantation, recapitulate the full spectrum of tumor progression. Pancreatic organoid technology provides a novel platform for the study of tumor biology and the discovery of potential biomarkers, therapeutics, and personalized medicine strategies.

AB - We recently established organoid models from normal and neoplastic murine and human pancreas tissues. These organoids exhibit ductal- and disease stage-specific characteristics and, after orthotopic transplantation, recapitulate the full spectrum of tumor progression. Pancreatic organoid technology provides a novel platform for the study of tumor biology and the discovery of potential biomarkers, therapeutics, and personalized medicine strategies.

KW - cancer

KW - organoids

KW - pancreatic ductal adenocarcinoma

KW - preclinical models

UR - https://www.scopus.com/pages/publications/84952640112

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DO - 10.1080/23723556.2015.1014757

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Model organoids provide new research opportunities for ductal pancreatic cancer

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