Modulation of glucocorticoid metabolism by the GH-IGF-I axis

Sebastian J.C.M.M. Neggers; Aart J. Van Der Lely

doi:10.1159/000321243

Modulation of glucocorticoid metabolism by the GH-IGF-I axis

Sebastian J.C.M.M. Neggers, Aart J. Van Der Lely

Onderzoeksoutput: Hoofdstuk in Boek/Rapport/Congresprocedure › Hoofdstuk › peer review

8 Citaten (Scopus)

Samenvatting

Growth hormone (GH) can generate insulin-like growth factor-I production, provided that the liver encounters portal insulin as a permissive factor that switches on the liver sensitivity for GH. This phenomenon is important for a proper insight into the pathophysiology of diseases as type 1 and 2 diabetes which differ in portal insulin levels. Also, acromegaly and obesity can be better understood when this effect of insulin on liver sensitivity for GH is taken into account. Moreover, as all of these factors seem to influence activity of the 11β-hydroxysteroid dehydrogenase (11β-HSD) type 1 (and 2), an extensive knowledge on the interplay between them is crucial as nowadays treatment options for obesity using the 11β-HSD1 are emerging.

Originele taal-2	Engels
Titel	Pediatric Adrenal Diseases
Redacteuren	Lucia Ghizzoni, George Chrousos, Mohamad Maghnie, Marco Cappa, Sandro Loche
Pagina's	181-186
Aantal pagina's	6
DOI's	https://doi.org/10.1159/000321243
Status	Gepubliceerd - dec. 2010
Extern gepubliceerd	Ja

Publicatie series

Naam	Endocrine Development
Volume	20
ISSN van geprinte versie	1421-7082
ISSN van elektronische versie	1662-2979

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abstract = "Growth hormone (GH) can generate insulin-like growth factor-I production, provided that the liver encounters portal insulin as a permissive factor that switches on the liver sensitivity for GH. This phenomenon is important for a proper insight into the pathophysiology of diseases as type 1 and 2 diabetes which differ in portal insulin levels. Also, acromegaly and obesity can be better understood when this effect of insulin on liver sensitivity for GH is taken into account. Moreover, as all of these factors seem to influence activity of the 11β-hydroxysteroid dehydrogenase (11β-HSD) type 1 (and 2), an extensive knowledge on the interplay between them is crucial as nowadays treatment options for obesity using the 11β-HSD1 are emerging.",

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Modulation of glucocorticoid metabolism by the GH-IGF-I axis. / Neggers, Sebastian J.C.M.M.; Van Der Lely, Aart J.
Pediatric Adrenal Diseases. uitgave / Lucia Ghizzoni; George Chrousos; Mohamad Maghnie; Marco Cappa; Sandro Loche. 2010. blz. 181-186 (Endocrine Development; Vol. 20).

Onderzoeksoutput: Hoofdstuk in Boek/Rapport/Congresprocedure › Hoofdstuk › peer review

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Modulation of glucocorticoid metabolism by the GH-IGF-I axis

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