Molecular characterization of a recurring complex chromosomal translocation in two human extragonadal germ cell tumors

R. J. Sinke; D. Olde Weghuis; R. F. Suijkerbuijk; A. Tanigami; Y. Nakamura; C. Larsson; G. Weber; B. de Jong; J. W. Oosterhuis; W. M. Molenaar; A. Geurts van Kessel

doi:10.1016/0165-4608(94)90176-7

Molecular characterization of a recurring complex chromosomal translocation in two human extragonadal germ cell tumors

R. J. Sinke, D. Olde Weghuis, R. F. Suijkerbuijk, A. Tanigami, Y. Nakamura, C. Larsson, G. Weber, B. de Jong, J. W. Oosterhuis, W. M. Molenaar, A. Geurts van Kessel

Onderzoeksoutput: Bijdrage aan tijdschrift › Artikel › peer review

25 Citaten (Scopus)

Samenvatting

The molecular characterization of a recurring complex chromosomal translocation involving 6p21, 6p22, 6q23, and 11q13 in two independent but similar extragonadal human germ cell tumors was initiated using fluorescence in situ hybridization (FISH) and pulse field gel electrophoresis (PFGE) techniques. By using a series of specific probes from the 11q13 region, the translocation breakpoint in this chromosomal band could be located within a long-range restriction enzyme map in between the markers D11S457 and D11S546. In addition, aberrantly hybridizing restriction fragments were revealed by PFGE in both tumors, indicating that the breakpoint region must be located within a distance of at maximum 200 kilobase pairs (kbp) from the nearest DNA marker (D11S546).

Originele taal-2	Engels
Pagina's (van-tot)	11-16
Aantal pagina's	6
Tijdschrift	Cancer Genetics and Cytogenetics
Volume	73
Nummer van het tijdschrift	1
DOI's	https://doi.org/10.1016/0165-4608(94)90176-7
Status	Gepubliceerd - mrt. 1994
Extern gepubliceerd	Ja

Toegang tot document

10.1016/0165-4608(94)90176-7

Citeer dit

Sinke, R. J., Olde Weghuis, D., Suijkerbuijk, R. F., Tanigami, A., Nakamura, Y., Larsson, C., Weber, G., de Jong, B., Oosterhuis, J. W., Molenaar, W. M., & Geurts van Kessel, A. (1994). Molecular characterization of a recurring complex chromosomal translocation in two human extragonadal germ cell tumors. Cancer Genetics and Cytogenetics, 73(1), 11-16. https://doi.org/10.1016/0165-4608(94)90176-7

@article{a329ff1dc3ed4dbdaf698fadf120c76d,

title = "Molecular characterization of a recurring complex chromosomal translocation in two human extragonadal germ cell tumors",

abstract = "The molecular characterization of a recurring complex chromosomal translocation involving 6p21, 6p22, 6q23, and 11q13 in two independent but similar extragonadal human germ cell tumors was initiated using fluorescence in situ hybridization (FISH) and pulse field gel electrophoresis (PFGE) techniques. By using a series of specific probes from the 11q13 region, the translocation breakpoint in this chromosomal band could be located within a long-range restriction enzyme map in between the markers D11S457 and D11S546. In addition, aberrantly hybridizing restriction fragments were revealed by PFGE in both tumors, indicating that the breakpoint region must be located within a distance of at maximum 200 kilobase pairs (kbp) from the nearest DNA marker (D11S546).",

author = "Sinke, {R. J.} and {Olde Weghuis}, D. and Suijkerbuijk, {R. F.} and A. Tanigami and Y. Nakamura and C. Larsson and G. Weber and {de Jong}, B. and Oosterhuis, {J. W.} and Molenaar, {W. M.} and {Geurts van Kessel}, A.",

year = "1994",

month = mar,

doi = "10.1016/0165-4608(94)90176-7",

language = "English",

volume = "73",

pages = "11--16",

journal = "Cancer Genetics and Cytogenetics",

issn = "0165-4608",

publisher = "Elsevier Inc.",

number = "1",

}

Sinke, RJ, Olde Weghuis, D, Suijkerbuijk, RF, Tanigami, A, Nakamura, Y, Larsson, C, Weber, G, de Jong, B, Oosterhuis, JW, Molenaar, WM & Geurts van Kessel, A 1994, 'Molecular characterization of a recurring complex chromosomal translocation in two human extragonadal germ cell tumors', Cancer Genetics and Cytogenetics, vol. 73, nr. 1, blz. 11-16. https://doi.org/10.1016/0165-4608(94)90176-7

TY - JOUR

T1 - Molecular characterization of a recurring complex chromosomal translocation in two human extragonadal germ cell tumors

AU - Sinke, R. J.

AU - Olde Weghuis, D.

AU - Suijkerbuijk, R. F.

AU - Tanigami, A.

AU - Nakamura, Y.

AU - Larsson, C.

AU - Weber, G.

AU - de Jong, B.

AU - Oosterhuis, J. W.

AU - Molenaar, W. M.

AU - Geurts van Kessel, A.

PY - 1994/3

Y1 - 1994/3

N2 - The molecular characterization of a recurring complex chromosomal translocation involving 6p21, 6p22, 6q23, and 11q13 in two independent but similar extragonadal human germ cell tumors was initiated using fluorescence in situ hybridization (FISH) and pulse field gel electrophoresis (PFGE) techniques. By using a series of specific probes from the 11q13 region, the translocation breakpoint in this chromosomal band could be located within a long-range restriction enzyme map in between the markers D11S457 and D11S546. In addition, aberrantly hybridizing restriction fragments were revealed by PFGE in both tumors, indicating that the breakpoint region must be located within a distance of at maximum 200 kilobase pairs (kbp) from the nearest DNA marker (D11S546).

AB - The molecular characterization of a recurring complex chromosomal translocation involving 6p21, 6p22, 6q23, and 11q13 in two independent but similar extragonadal human germ cell tumors was initiated using fluorescence in situ hybridization (FISH) and pulse field gel electrophoresis (PFGE) techniques. By using a series of specific probes from the 11q13 region, the translocation breakpoint in this chromosomal band could be located within a long-range restriction enzyme map in between the markers D11S457 and D11S546. In addition, aberrantly hybridizing restriction fragments were revealed by PFGE in both tumors, indicating that the breakpoint region must be located within a distance of at maximum 200 kilobase pairs (kbp) from the nearest DNA marker (D11S546).

UR - http://www.scopus.com/inward/record.url?scp=0028263579&partnerID=8YFLogxK

U2 - 10.1016/0165-4608(94)90176-7

DO - 10.1016/0165-4608(94)90176-7

M3 - Article

C2 - 8174069

AN - SCOPUS:0028263579

SN - 0165-4608

VL - 73

SP - 11

EP - 16

JO - Cancer Genetics and Cytogenetics

JF - Cancer Genetics and Cytogenetics

IS - 1

ER -

Molecular characterization of a recurring complex chromosomal translocation in two human extragonadal germ cell tumors

Samenvatting

Toegang tot document

Vingerafdruk

Citeer dit