Molecular-genetic insights in paediatric T-cell acute lymphoblastic leukaemia

Pieter Van Vlierberghe, Rob Pieters, H. Berna Beverloo, Jules P.P. Meijerink

Onderzoeksoutput: Bijdrage aan tijdschriftArtikel recenserenpeer review

130 Citaten (Scopus)

Samenvatting

Paediatric T-cell acute lymphoblastic leukaemia (T-ALL) is an aggressive malignancy of thymocytes that accounts for about 15% of ALL cases and for which treatment outcome remains inferior compared to B-lineage acute leukaemias. In T-ALL, leukemic transformation of maturating thymocytes is caused by a multistep pathogenesis involving numerous genetic abnormalities that drive normal T-cells into uncontrolled cell growth and clonal expansion. This review provides an overview of the current knowledge on onco- and tumor suppressor genes in T-ALL and suggests a classification of these genetic defects into type A and type B abnormalities. Type A abnormalities may delineate distinct molecular-cytogenetic T-ALL subgroups, whereas type B abnormalities are found in all major T-ALL subgroups and synergize with these type A mutations during T-cell pathogenesis.

Originele taal-2Engels
Pagina's (van-tot)153-168
Aantal pagina's16
TijdschriftBritish Journal of Haematology
Volume143
Nummer van het tijdschrift2
DOI's
StatusGepubliceerd - okt. 2008
Extern gepubliceerdJa

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