Molecular mechanisms of 5-fluorocytosine resistance in yeasts and filamentous fungi

Fatima Zohra Delma; Abdullah M.S. Al-Hatmi; Roger J.M. Brüggemann; Willem J.G. Melchers; Sybren de Hoog; Paul E. Verweij; Jochem B. Buil

doi:10.3390/jof7110909

Molecular mechanisms of 5-fluorocytosine resistance in yeasts and filamentous fungi

Fatima Zohra Delma, Abdullah M.S. Al-Hatmi, Roger J.M. Brüggemann, Willem J.G. Melchers, Sybren de Hoog, Paul E. Verweij, Jochem B. Buil

Onderzoeksoutput: Bijdrage aan tijdschrift › Artikel recenseren › peer review

39 Citaten (Scopus)

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Effective management and treatment of fungal diseases is hampered by poor diagnosis, limited options for antifungal therapy, and the emergence of antifungal drug resistance. An understanding of molecular mechanisms contributing to resistance is essential to optimize the efficacy of currently available antifungals. In this perspective, one of the oldest antifungals, 5-fluorocytosine (5-FC), has been the focus of recent studies applying advanced genomic and transcriptomic techniques to decipher the order of events at the molecular level that lead to resistance. These studies have highlighted the complexity of resistance and provided new insights that are reviewed in the present paper.

Originele taal-2	Engels
Artikelnummer	909
Tijdschrift	Journal of Fungi
Volume	7
Nummer van het tijdschrift	11
DOI's	https://doi.org/10.3390/jof7110909
Status	Gepubliceerd - nov. 2021
Extern gepubliceerd	Ja

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title = "Molecular mechanisms of 5-fluorocytosine resistance in yeasts and filamentous fungi",

abstract = "Effective management and treatment of fungal diseases is hampered by poor diagnosis, limited options for antifungal therapy, and the emergence of antifungal drug resistance. An understanding of molecular mechanisms contributing to resistance is essential to optimize the efficacy of currently available antifungals. In this perspective, one of the oldest antifungals, 5-fluorocytosine (5-FC), has been the focus of recent studies applying advanced genomic and transcriptomic techniques to decipher the order of events at the molecular level that lead to resistance. These studies have highlighted the complexity of resistance and provided new insights that are reviewed in the present paper.",

keywords = "5-fluorocytosine, Molecular mechanisms, Resistance",

author = "Delma, {Fatima Zohra} and Al-Hatmi, {Abdullah M.S.} and Br{\"u}ggemann, {Roger J.M.} and Melchers, {Willem J.G.} and {de Hoog}, Sybren and Verweij, {Paul E.} and Buil, {Jochem B.}",

note = "Publisher Copyright: {\textcopyright} 2021 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2021",

month = nov,

doi = "10.3390/jof7110909",

language = "English",

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T1 - Molecular mechanisms of 5-fluorocytosine resistance in yeasts and filamentous fungi

AU - Delma, Fatima Zohra

AU - Al-Hatmi, Abdullah M.S.

AU - Brüggemann, Roger J.M.

AU - Melchers, Willem J.G.

AU - de Hoog, Sybren

AU - Verweij, Paul E.

AU - Buil, Jochem B.

PY - 2021/11

Y1 - 2021/11

N2 - Effective management and treatment of fungal diseases is hampered by poor diagnosis, limited options for antifungal therapy, and the emergence of antifungal drug resistance. An understanding of molecular mechanisms contributing to resistance is essential to optimize the efficacy of currently available antifungals. In this perspective, one of the oldest antifungals, 5-fluorocytosine (5-FC), has been the focus of recent studies applying advanced genomic and transcriptomic techniques to decipher the order of events at the molecular level that lead to resistance. These studies have highlighted the complexity of resistance and provided new insights that are reviewed in the present paper.

AB - Effective management and treatment of fungal diseases is hampered by poor diagnosis, limited options for antifungal therapy, and the emergence of antifungal drug resistance. An understanding of molecular mechanisms contributing to resistance is essential to optimize the efficacy of currently available antifungals. In this perspective, one of the oldest antifungals, 5-fluorocytosine (5-FC), has been the focus of recent studies applying advanced genomic and transcriptomic techniques to decipher the order of events at the molecular level that lead to resistance. These studies have highlighted the complexity of resistance and provided new insights that are reviewed in the present paper.

KW - 5-fluorocytosine

KW - Molecular mechanisms

KW - Resistance

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U2 - 10.3390/jof7110909

DO - 10.3390/jof7110909

M3 - Review article

AN - SCOPUS:85118100912

SN - 2309-608X

VL - 7

JO - Journal of Fungi

JF - Journal of Fungi

IS - 11

M1 - 909

ER -

Molecular mechanisms of 5-fluorocytosine resistance in yeasts and filamentous fungi

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