Molecular mechanisms of 5-fluorocytosine resistance in yeasts and filamentous fungi

Fatima Zohra Delma, Abdullah M.S. Al-Hatmi, Roger J.M. Brüggemann, Willem J.G. Melchers, Sybren de Hoog, Paul E. Verweij, Jochem B. Buil

Onderzoeksoutput: Bijdrage aan tijdschriftArtikel recenserenpeer review

25 Citaten (Scopus)


Effective management and treatment of fungal diseases is hampered by poor diagnosis, limited options for antifungal therapy, and the emergence of antifungal drug resistance. An understanding of molecular mechanisms contributing to resistance is essential to optimize the efficacy of currently available antifungals. In this perspective, one of the oldest antifungals, 5-fluorocytosine (5-FC), has been the focus of recent studies applying advanced genomic and transcriptomic techniques to decipher the order of events at the molecular level that lead to resistance. These studies have highlighted the complexity of resistance and provided new insights that are reviewed in the present paper.

Originele taal-2Engels
TijdschriftJournal of Fungi
Nummer van het tijdschrift11
StatusGepubliceerd - nov. 2021
Extern gepubliceerdJa


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