Muismutanten als model voor humane verouderingsziekten. Verstoorde transcriptie en vroegtijdige veroudering

J. De Boer; G. T.J. Van der Horst; J. H.J. Hoeijmakers

Muismutanten als model voor humane verouderingsziekten. Verstoorde transcriptie en vroegtijdige veroudering

J. De Boer, G. T.J. Van der Horst, J. H.J. Hoeijmakers

Onderzoeksoutput: Bijdrage aan tijdschrift › Artikel › peer review

4 Citaten (Scopus)

Samenvatting

DNA damage has been implicated in carcinogenesis and ageing. Our group examines the nucleotide excision DNA repair (NER) process, which can detect and repair various UV- and chemically-induced DNA damages, in addition to some types of oxidative DNA damage. Recently, two mouse models were generated with a defect in one of the NER genes (XPD and CSB), displaying distinctive symptoms of premature ageing. Remarkably, in both cases the NER gene plays an additional role in transcription. Research using these mouse models aims to investigate the link between premature ageing and molecular defects in NER and transcription.

Vertaalde titel van de bijdrage	Mouse mutants as model for human ageing disorders. Defective transcription and premature ageing
Originele taal-2	Nederlands
Pagina's (van-tot)	168-170
Aantal pagina's	3
Tijdschrift	Tijdschrift voor Gerontologie en Geriatrie
Volume	30
Nummer van het tijdschrift	4
Status	Gepubliceerd - 1999
Extern gepubliceerd	Ja

Trefwoorden

DNA-herstel
Muismodel
Veroudering
Xeroderma pigmentosum

Citeer dit

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abstract = "DNA damage has been implicated in carcinogenesis and ageing. Our group examines the nucleotide excision DNA repair (NER) process, which can detect and repair various UV- and chemically-induced DNA damages, in addition to some types of oxidative DNA damage. Recently, two mouse models were generated with a defect in one of the NER genes (XPD and CSB), displaying distinctive symptoms of premature ageing. Remarkably, in both cases the NER gene plays an additional role in transcription. Research using these mouse models aims to investigate the link between premature ageing and molecular defects in NER and transcription.",

keywords = "DNA-herstel, Muismodel, Veroudering, Xeroderma pigmentosum",

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AU - Hoeijmakers, J. H.J.

PY - 1999

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AB - DNA damage has been implicated in carcinogenesis and ageing. Our group examines the nucleotide excision DNA repair (NER) process, which can detect and repair various UV- and chemically-induced DNA damages, in addition to some types of oxidative DNA damage. Recently, two mouse models were generated with a defect in one of the NER genes (XPD and CSB), displaying distinctive symptoms of premature ageing. Remarkably, in both cases the NER gene plays an additional role in transcription. Research using these mouse models aims to investigate the link between premature ageing and molecular defects in NER and transcription.

KW - DNA-herstel

KW - Muismodel

KW - Veroudering

KW - Xeroderma pigmentosum

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Muismutanten als model voor humane verouderingsziekten. Verstoorde transcriptie en vroegtijdige veroudering

Samenvatting

Trefwoorden

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