Multipotent stem cells from adult olfactory mucosa

Wayne Murrell, François Féron, Andrew Wetzig, Nick Cameron, Karisha Splatt, Bernadette Bellette, John Bianco, Chris Perry, Gabriel Lee, Alan Mackay-Sim

Onderzoeksoutput: Bijdrage aan tijdschriftArtikelpeer review

244 Citaten (Scopus)

Samenvatting

Multipotent stem cells are thought to be responsible for the generation of new neurons in the adult brain. Neurogenesis also occurs in an accessible part of the nervous system, the olfactory mucosa. We show here that cells from human olfactory mucosa generate neurospheres that are multipotent in vitro and when transplanted into the chicken embryo. Cloned neurosphere cells show this multipotency. Multipotency was evident without prior culture in vitro: cells dissociated from adult rat olfactory mucosa generate leukocytes when transplanted into bone marrow-irradiated hosts, and cells dissociated from adult mouse olfactory epithelium generated numerous cell types when transplanted into the chicken embryo. It is unlikely that these results can be attributed to hematopoietic precursor contamination or cell fusion. These results demonstrate the existence of a multipotent stem-like cell in the olfactory mucosa useful for autologous transplantation therapies and for cellular studies of disease.

Originele taal-2Engels
Pagina's (van-tot)496-515
Aantal pagina's20
TijdschriftDevelopmental Dynamics
Volume233
Nummer van het tijdschrift2
DOI's
StatusGepubliceerd - jun. 2005
Extern gepubliceerdJa

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