Mutation analysis of the BRAF oncogene in juvenile myelomonocytic leukemia

Andrica C.H. De Vries; Ronald W. Stam; Christian P. Kratz; Martin Zenker; Charlotte M. Niemeyer; Marry M. Van Den Heuvel-Eibrink

doi:10.3324/haematol.11493

Mutation analysis of the BRAF oncogene in juvenile myelomonocytic leukemia

Andrica C.H. De Vries, Ronald W. Stam, Christian P. Kratz, Martin Zenker, Charlotte M. Niemeyer, Marry M. Van Den Heuvel-Eibrink

Onderzoeksoutput: Bijdrage aan tijdschrift › Artikel › peer review

13 Citaten (Scopus)

Samenvatting

Juvenile myelomonocytic leukemia (JMML) is a myeloproliferative/ myelodysplastic disorder associated with mutations in the Ras-Raf-MEK-ERK- signaling pathway. B-Raf plays a central role in this pathway. In 65 screened JMML patients we identified no BRAF mutations and we conclude that this gene is unlikely to play a role in the pathogenesis of JMML.

Originele taal-2	Engels
Pagina's (van-tot)	1574-1575
Aantal pagina's	2
Tijdschrift	Haematologica
Volume	92
Nummer van het tijdschrift	11
DOI's	https://doi.org/10.3324/haematol.11493
Status	Gepubliceerd - nov. 2007
Extern gepubliceerd	Ja

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title = "Mutation analysis of the BRAF oncogene in juvenile myelomonocytic leukemia",

abstract = "Juvenile myelomonocytic leukemia (JMML) is a myeloproliferative/ myelodysplastic disorder associated with mutations in the Ras-Raf-MEK-ERK- signaling pathway. B-Raf plays a central role in this pathway. In 65 screened JMML patients we identified no BRAF mutations and we conclude that this gene is unlikely to play a role in the pathogenesis of JMML.",

keywords = "BRAF, Juvenile myelomonocytic leukemia",

author = "\{De Vries\}, \{Andrica C.H.\} and Stam, \{Ronald W.\} and Kratz, \{Christian P.\} and Martin Zenker and Niemeyer, \{Charlotte M.\} and \{Van Den Heuvel-Eibrink\}, \{Marry M.\}",

year = "2007",

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AU - De Vries, Andrica C.H.

AU - Stam, Ronald W.

AU - Kratz, Christian P.

AU - Zenker, Martin

AU - Niemeyer, Charlotte M.

AU - Van Den Heuvel-Eibrink, Marry M.

PY - 2007/11

Y1 - 2007/11

N2 - Juvenile myelomonocytic leukemia (JMML) is a myeloproliferative/ myelodysplastic disorder associated with mutations in the Ras-Raf-MEK-ERK- signaling pathway. B-Raf plays a central role in this pathway. In 65 screened JMML patients we identified no BRAF mutations and we conclude that this gene is unlikely to play a role in the pathogenesis of JMML.

AB - Juvenile myelomonocytic leukemia (JMML) is a myeloproliferative/ myelodysplastic disorder associated with mutations in the Ras-Raf-MEK-ERK- signaling pathway. B-Raf plays a central role in this pathway. In 65 screened JMML patients we identified no BRAF mutations and we conclude that this gene is unlikely to play a role in the pathogenesis of JMML.

KW - BRAF

KW - Juvenile myelomonocytic leukemia

UR - https://www.scopus.com/pages/publications/36348986709

U2 - 10.3324/haematol.11493

DO - 10.3324/haematol.11493

M3 - Article

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AN - SCOPUS:36348986709

SN - 0390-6078

VL - 92

SP - 1574

EP - 1575

JO - Haematologica

JF - Haematologica

IS - 11

ER -

Mutation analysis of the BRAF oncogene in juvenile myelomonocytic leukemia

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