Mutation of genes affecting the RAS pathway is common in childhood acute lymphoblastic leukemia

Keyphrases

• Acute Lymphoblastic Leukemia 33%
• Allele-specific PCR 33%
• Childhood Acute Lymphoblastic Leukemia 100%
• Clinical Trials 33%
• Denaturing High-performance Liquid Chromatography (DHPLC) 33%
• Deregulation 33%
• Differential Cytotoxicity 33%
• Disease Progression 33%
• Encoded Protein 33%
• Exon 33%
• Extracellular Signal-regulated Kinase 66%
• Extracellular Signal-regulated Kinase Signaling 33%
• FMS-like Tyrosine Kinase 3 (FLT3) 33%
• Gene Encoding 33%
• Gene mutation 100%
• Genetic Aberrations 33%
• Kinase Inhibitor 33%
• KRAS2 33%
• Large Cohort 33%
• Mitogen-activated Protein Kinase/extracellular Signal-regulated Kinase 33%
• Novel Therapeutics 33%
• PTPN11 33%
• RAS Pathway 100%
• Recurrent Disease 33%
• Signaling Cascades 33%
• Somatic mutation 66%
• Working Diagnosis 66%

Biochemistry, Genetics and Molecular Biology

• Allele 25%
• Clinical Trial 25%
• Cytotoxicity 25%
• Denaturing High Performance Liquid Chromatography 25%
• Exon 25%
• Extracellular Signal-Regulated Kinases 100%
• Genetics 25%
• Kinase 25%
• Mitogen-Activated Protein Kinase 25%
• Phosphotransferase 25%
• PTPN11 25%
• Somatic Mutation 50%