Myocyte enhancer factor 2C in hematopoiesis and leukemia

K. Canté-Barrett; R. Pieters; J. P.P. Meijerink

doi:10.1038/onc.2013.56

Myocyte enhancer factor 2C in hematopoiesis and leukemia

K. Canté-Barrett, R. Pieters, J. P.P. Meijerink

Onderzoeksoutput: Bijdrage aan tijdschrift › Artikel recenseren › peer review

75 Citaten (Scopus)

Samenvatting

MEF2C is a selectively expressed transcription factor involved in different transcriptional complexes. Originally identified as an essential regulator of muscle development, ectopic expression of MEF2C as a result of chromosomal rearrangements is now linked to leukemia. Specifically, high MEF2C expression has been linked to mixed lineage leukemia-rearranged acute myeloid leukemia as well as to the immature subgroup of T-cell acute lymphoblastic leukemia. This review focuses on the role of MEF2C in the hematopoietic system and on aberrant MEF2C expression in human leukemia.

Originele taal-2	Engels
Pagina's (van-tot)	403-410
Aantal pagina's	8
Tijdschrift	Oncogene
Volume	33
Nummer van het tijdschrift	4
DOI's	https://doi.org/10.1038/onc.2013.56
Status	Gepubliceerd - 23 jan. 2014
Extern gepubliceerd	Ja

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title = "Myocyte enhancer factor 2C in hematopoiesis and leukemia",

abstract = "MEF2C is a selectively expressed transcription factor involved in different transcriptional complexes. Originally identified as an essential regulator of muscle development, ectopic expression of MEF2C as a result of chromosomal rearrangements is now linked to leukemia. Specifically, high MEF2C expression has been linked to mixed lineage leukemia-rearranged acute myeloid leukemia as well as to the immature subgroup of T-cell acute lymphoblastic leukemia. This review focuses on the role of MEF2C in the hematopoietic system and on aberrant MEF2C expression in human leukemia.",

keywords = "Hematopoiesis, Leukemia, MEF2C",

author = "K. Cant{\'e}-Barrett and R. Pieters and Meijerink, \{J. P.P.\}",

note = "Funding Information: This work is supported by the Children Cancer Free Foundation (Stichting Kinderen Kankervrij (KIKA), 2008-029 (KCB)).",

year = "2014",

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doi = "10.1038/onc.2013.56",

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AU - Pieters, R.

AU - Meijerink, J. P.P.

N1 - Funding Information: This work is supported by the Children Cancer Free Foundation (Stichting Kinderen Kankervrij (KIKA), 2008-029 (KCB)).

PY - 2014/1/23

Y1 - 2014/1/23

N2 - MEF2C is a selectively expressed transcription factor involved in different transcriptional complexes. Originally identified as an essential regulator of muscle development, ectopic expression of MEF2C as a result of chromosomal rearrangements is now linked to leukemia. Specifically, high MEF2C expression has been linked to mixed lineage leukemia-rearranged acute myeloid leukemia as well as to the immature subgroup of T-cell acute lymphoblastic leukemia. This review focuses on the role of MEF2C in the hematopoietic system and on aberrant MEF2C expression in human leukemia.

AB - MEF2C is a selectively expressed transcription factor involved in different transcriptional complexes. Originally identified as an essential regulator of muscle development, ectopic expression of MEF2C as a result of chromosomal rearrangements is now linked to leukemia. Specifically, high MEF2C expression has been linked to mixed lineage leukemia-rearranged acute myeloid leukemia as well as to the immature subgroup of T-cell acute lymphoblastic leukemia. This review focuses on the role of MEF2C in the hematopoietic system and on aberrant MEF2C expression in human leukemia.

KW - Hematopoiesis

KW - Leukemia

KW - MEF2C

UR - https://www.scopus.com/pages/publications/84897018519

U2 - 10.1038/onc.2013.56

DO - 10.1038/onc.2013.56

M3 - Review article

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JO - Oncogene

JF - Oncogene

IS - 4

ER -

Myocyte enhancer factor 2C in hematopoiesis and leukemia

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