Nephroblastoma: Does the decrease in tumor volume under preoperative chemotherapy predict the lymph nodes status at surgery?

Jan Godzinski, Harm van Tinteren, Jan de Kraker, Norbert Graf, Christophe Bergeron, Hugo Heij, Dietrich von Schweinitz, Joerg Fuchs, Giovanni Cecchetto, George Audry, Frederic Gauthier, Bengt Sandstedt

Onderzoeksoutput: Bijdrage aan tijdschriftArtikelpeer review

26 Citaten (Scopus)


Background: Partial nephrectomy (NSS) for unilateral nephroblastoma may be beneficial, although in case of regional lymph node (LN) involvement, radiotherapy counteracts the functional benefit of NSS. The aim is to verify whether decrease of tumor volume under preoperative chemotherapy implies clearance of regional LN. Procedure: SIOP 9301 (1993-2001) collected 1,450 localized nephroblastoma patients of whom 1,360 (93%) had sufficiently available data and were retrospectively reviewed. Results: Histologic subtypes were classically distributed. Patients were divided in those with tumor positive LN (76, 5.5%) and those with tumor negative LN (1,284, 94.5%) at surgery. In the LN(+) group, the tumor volume changed from a median of 554 (318-772) to 192 (63-458)ml=67% (27-88%) during preoperative ChT. In the LN(-) group-377 (200-612) to 130 (44-294)ml=62% (28-83%) (NS). Increase of tumor volume was observed in 16% of patients with LN(+), and 11% of those with LN(-) (NS); ranges are interquartile. Initial tumor volume was significantly larger in the LN(+) patients (P=0.00091) but not different (NS) at surgery; patients with initial tumor volume under 318ml had the regional LN involved significantly less frequently (P=0.00751). Conclusions: Change in tumor volume under preoperative chemotherapy is not a predictor for LN status at surgery, although larger initial volume is associated with a higher risk of LN invasion. The decrease of tumor volume is not a good criterion for the safety of NSS. The low rate of LN(+) (5.5%) indicates that this risk is low.

Originele taal-2Engels
Pagina's (van-tot)1266-1269
Aantal pagina's4
TijdschriftPediatric Blood and Cancer
Nummer van het tijdschrift7
StatusGepubliceerd - 15 dec. 2011
Extern gepubliceerdJa


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