New genetic abnormalities and treatment response in acute lymphoblastic leukemia

Jules P P Meijerink; Monique L den Boer; Rob Pieters

doi:10.1053/j.seminhematol.2008.09.006

New genetic abnormalities and treatment response in acute lymphoblastic leukemia

Jules P P Meijerink, Monique L den Boer, Rob Pieters

Onderzoeksoutput: Bijdrage aan tijdschrift › Artikel recenseren › peer review

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Numerous genetic abnormalities have been identified in acute lymphoblastic leukemia (ALL). Here we review the recurrent abnormalities with emphasis on those recently discovered, and discuss their association with chemotherapy resistance or sensitivity and with clinical response to therapy. Also, the role of genetic abnormalities in leukemogenesis and their potential as therapeutic targets will be discussed.

Originele taal-2	Engels
Pagina's (van-tot)	16-23
Aantal pagina's	8
Tijdschrift	Seminars in hematology
Volume	46
Nummer van het tijdschrift	1
DOI's	https://doi.org/10.1053/j.seminhematol.2008.09.006
Status	Gepubliceerd - jan. 2009
Extern gepubliceerd	Ja

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title = "New genetic abnormalities and treatment response in acute lymphoblastic leukemia",

abstract = "Numerous genetic abnormalities have been identified in acute lymphoblastic leukemia (ALL). Here we review the recurrent abnormalities with emphasis on those recently discovered, and discuss their association with chemotherapy resistance or sensitivity and with clinical response to therapy. Also, the role of genetic abnormalities in leukemogenesis and their potential as therapeutic targets will be discussed.",

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author = "Meijerink, {Jules P P} and {den Boer}, {Monique L} and Rob Pieters",

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KW - Child, Preschool

KW - Chromosome Aberrations

KW - Gene Expression Regulation, Leukemic

KW - Humans

KW - Mutation

KW - Precursor B-Cell Lymphoblastic Leukemia-Lymphoma/drug therapy

KW - Precursor T-Cell Lymphoblastic Leukemia-Lymphoma/drug therapy

KW - Transcription Factors/genetics

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New genetic abnormalities and treatment response in acute lymphoblastic leukemia

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