New genetic abnormalities and treatment response in acute lymphoblastic leukemia

Jules P P Meijerink; Monique L den Boer; Rob Pieters

doi:10.1053/j.seminhematol.2008.09.006

New genetic abnormalities and treatment response in acute lymphoblastic leukemia

Jules P P Meijerink
, Monique L den Boer
, Rob Pieters

Onderzoeksoutput: Bijdrage aan tijdschrift › Artikel recenseren › peer review

47 Citaten (Scopus)

Samenvatting

Numerous genetic abnormalities have been identified in acute lymphoblastic leukemia (ALL). Here we review the recurrent abnormalities with emphasis on those recently discovered, and discuss their association with chemotherapy resistance or sensitivity and with clinical response to therapy. Also, the role of genetic abnormalities in leukemogenesis and their potential as therapeutic targets will be discussed.

Originele taal-2	Engels
Pagina's (van-tot)	16-23
Aantal pagina's	8
Tijdschrift	Seminars in hematology
Volume	46
Nummer van het tijdschrift	1
DOI's	https://doi.org/10.1053/j.seminhematol.2008.09.006
Status	Gepubliceerd - jan 2009
Extern gepubliceerd	Ja

Toegang tot document

10.1053/j.seminhematol.2008.09.006

Citeer dit

@article{1c2a2137d6f44b01be10b61eeb189cc0,

title = "New genetic abnormalities and treatment response in acute lymphoblastic leukemia",

abstract = "Numerous genetic abnormalities have been identified in acute lymphoblastic leukemia (ALL). Here we review the recurrent abnormalities with emphasis on those recently discovered, and discuss their association with chemotherapy resistance or sensitivity and with clinical response to therapy. Also, the role of genetic abnormalities in leukemogenesis and their potential as therapeutic targets will be discussed.",

keywords = "Child, Child, Preschool, Chromosome Aberrations, Gene Expression Regulation, Leukemic, Humans, Mutation, Precursor B-Cell Lymphoblastic Leukemia-Lymphoma/drug therapy, Precursor T-Cell Lymphoblastic Leukemia-Lymphoma/drug therapy, Transcription Factors/genetics",

author = "Meijerink, \{Jules P P\} and \{den Boer\}, \{Monique L\} and Rob Pieters",

year = "2009",

month = jan,

doi = "10.1053/j.seminhematol.2008.09.006",

language = "English",

volume = "46",

pages = "16--23",

journal = "Seminars in hematology",

issn = "0037-1963",

publisher = "W.B. Saunders",

number = "1",

}

TY - JOUR

T1 - New genetic abnormalities and treatment response in acute lymphoblastic leukemia

AU - Meijerink, Jules P P

AU - den Boer, Monique L

AU - Pieters, Rob

PY - 2009/1

Y1 - 2009/1

N2 - Numerous genetic abnormalities have been identified in acute lymphoblastic leukemia (ALL). Here we review the recurrent abnormalities with emphasis on those recently discovered, and discuss their association with chemotherapy resistance or sensitivity and with clinical response to therapy. Also, the role of genetic abnormalities in leukemogenesis and their potential as therapeutic targets will be discussed.

AB - Numerous genetic abnormalities have been identified in acute lymphoblastic leukemia (ALL). Here we review the recurrent abnormalities with emphasis on those recently discovered, and discuss their association with chemotherapy resistance or sensitivity and with clinical response to therapy. Also, the role of genetic abnormalities in leukemogenesis and their potential as therapeutic targets will be discussed.

KW - Child

KW - Child, Preschool

KW - Chromosome Aberrations

KW - Gene Expression Regulation, Leukemic

KW - Humans

KW - Mutation

KW - Precursor B-Cell Lymphoblastic Leukemia-Lymphoma/drug therapy

KW - Precursor T-Cell Lymphoblastic Leukemia-Lymphoma/drug therapy

KW - Transcription Factors/genetics

U2 - 10.1053/j.seminhematol.2008.09.006

DO - 10.1053/j.seminhematol.2008.09.006

M3 - Review article

C2 - 19100364

SN - 0037-1963

VL - 46

SP - 16

EP - 23

JO - Seminars in hematology

JF - Seminars in hematology

IS - 1

ER -

New genetic abnormalities and treatment response in acute lymphoblastic leukemia

Samenvatting

Toegang tot document

Vingerafdruk

Citeer dit