Samenvatting
Background. Long-term writing difficulties in children after treatment with vincristine for acute lymphoblastic leukemia, Wilms tumor, B non-Hodgkin lymphoma, and malignant mesenchymal tumors, were investigated. Procedure. Handwriting of 33 survivors and 33 controls matched for age, sex, and grade, was assessed with the BHK-scale. The examiner was blinded for whether a child was a case or a control. Results. No significant difference in writing speed was found. Mean difference in number of letters produced during 5 min was 6.4 (±67.1, range -103 to +169). No significant difference was found in quality of writing scores; mean difference in points was 1.5 (±7.7, range -19 to +22). Cumulative vincristine dose, age at diagnosis or time since completion of treatment did not affect writing speed or quality. Conclusion. Chemotherapy, including vincristine, does not lead to long-term problems in speed or quality of writing in children treated for cancer.
Originele taal-2 | Engels |
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Pagina's (van-tot) | 841-845 |
Aantal pagina's | 5 |
Tijdschrift | Pediatric Blood and Cancer |
Volume | 49 |
Nummer van het tijdschrift | 6 |
DOI's | |
Status | Gepubliceerd - nov. 2007 |
Extern gepubliceerd | Ja |