No adverse effect of vincristine on handwriting in children after completion of therapy

A. Hartman, C. Van Den Bos, N. Van Dartel, Th Stijnen, R. Pieters

Onderzoeksoutput: Bijdrage aan tijdschriftArtikelpeer review

8 Citaten (Scopus)

Samenvatting

Background. Long-term writing difficulties in children after treatment with vincristine for acute lymphoblastic leukemia, Wilms tumor, B non-Hodgkin lymphoma, and malignant mesenchymal tumors, were investigated. Procedure. Handwriting of 33 survivors and 33 controls matched for age, sex, and grade, was assessed with the BHK-scale. The examiner was blinded for whether a child was a case or a control. Results. No significant difference in writing speed was found. Mean difference in number of letters produced during 5 min was 6.4 (±67.1, range -103 to +169). No significant difference was found in quality of writing scores; mean difference in points was 1.5 (±7.7, range -19 to +22). Cumulative vincristine dose, age at diagnosis or time since completion of treatment did not affect writing speed or quality. Conclusion. Chemotherapy, including vincristine, does not lead to long-term problems in speed or quality of writing in children treated for cancer.

Originele taal-2Engels
Pagina's (van-tot)841-845
Aantal pagina's5
TijdschriftPediatric Blood and Cancer
Volume49
Nummer van het tijdschrift6
DOI's
StatusGepubliceerd - nov. 2007
Extern gepubliceerdJa

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