No significant prognostic value of normal precursor B-cell regeneration in paediatric acute myeloid leukaemia after induction treatment

Anne E. Bras; Marry M. Van den Heuvel-Eibrink; Alita J. Van der Sluijs-Gelling; Eva A. Coenen; Henk Wind; C. Michel Zwaan; Jeroen G. Te Marvelde; Mirjam Van der Burg; Brenda Gibson; Anita W. Rijneveld; Valérie De Haas; Jacques J.M. Van Dongen; Vincent H.J. Van der Velden

doi:10.1111/bjh.12329

No significant prognostic value of normal precursor B-cell regeneration in paediatric acute myeloid leukaemia after induction treatment

Anne E. Bras, Marry M. Van den Heuvel-Eibrink, Alita J. Van der Sluijs-Gelling, Eva A. Coenen, Henk Wind, C. Michel Zwaan, Jeroen G. Te Marvelde, Mirjam Van der Burg, Brenda Gibson, Anita W. Rijneveld, Valérie De Haas, Jacques J.M. Van Dongen, Vincent H.J. Van der Velden

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6 Citaten (Scopus)

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B-cell precursors (BCP) regeneration in bone marrow (BM) after induction chemotherapy is prognostic for good treatment response in adult acute myeloid leukaemia (AML). We detected BCP regeneration in 81% of 59 paediatric AML patients at first complete remission; this compared to 46% in an adult study. BCP regeneration did not correlate with outcome or minimal residual disease levels. In 36 healthy BM controls, BCP levels were significantly higher in children as compared to adults. Therefore, BCP regeneration does not reflect good response to treatment in paediatric AML, possibly due to the relatively high base-line levels of BCP in children.

Originele taal-2	Engels
Pagina's (van-tot)	861-864
Aantal pagina's	4
Tijdschrift	British Journal of Haematology
Volume	161
Nummer van het tijdschrift	6
DOI's	https://doi.org/10.1111/bjh.12329
Status	Gepubliceerd - jun. 2013
Extern gepubliceerd	Ja

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Bras, A. E., Van den Heuvel-Eibrink, M. M., Van der Sluijs-Gelling, A. J., Coenen, E. A., Wind, H., Zwaan, C. M., Te Marvelde, J. G., Van der Burg, M., Gibson, B., Rijneveld, A. W., De Haas, V., Van Dongen, J. J. M., & Van der Velden, V. H. J. (2013). No significant prognostic value of normal precursor B-cell regeneration in paediatric acute myeloid leukaemia after induction treatment. British Journal of Haematology, 161(6), 861-864. https://doi.org/10.1111/bjh.12329

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title = "No significant prognostic value of normal precursor B-cell regeneration in paediatric acute myeloid leukaemia after induction treatment",

abstract = "B-cell precursors (BCP) regeneration in bone marrow (BM) after induction chemotherapy is prognostic for good treatment response in adult acute myeloid leukaemia (AML). We detected BCP regeneration in 81% of 59 paediatric AML patients at first complete remission; this compared to 46% in an adult study. BCP regeneration did not correlate with outcome or minimal residual disease levels. In 36 healthy BM controls, BCP levels were significantly higher in children as compared to adults. Therefore, BCP regeneration does not reflect good response to treatment in paediatric AML, possibly due to the relatively high base-line levels of BCP in children.",

keywords = "AML, B-cells, MRD, Paediatric, Relapse",

author = "Bras, {Anne E.} and {Van den Heuvel-Eibrink}, {Marry M.} and {Van der Sluijs-Gelling}, {Alita J.} and Coenen, {Eva A.} and Henk Wind and Zwaan, {C. Michel} and {Te Marvelde}, {Jeroen G.} and {Van der Burg}, Mirjam and Brenda Gibson and Rijneveld, {Anita W.} and {De Haas}, Val{\'e}rie and {Van Dongen}, {Jacques J.M.} and {Van der Velden}, {Vincent H.J.}",

year = "2013",

month = jun,

doi = "10.1111/bjh.12329",

language = "English",

volume = "161",

pages = "861--864",

journal = "British Journal of Haematology",

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Bras, AE, Van den Heuvel-Eibrink, MM, Van der Sluijs-Gelling, AJ, Coenen, EA, Wind, H, Zwaan, CM, Te Marvelde, JG, Van der Burg, M, Gibson, B, Rijneveld, AW, De Haas, V, Van Dongen, JJM & Van der Velden, VHJ 2013, 'No significant prognostic value of normal precursor B-cell regeneration in paediatric acute myeloid leukaemia after induction treatment', British Journal of Haematology, vol. 161, nr. 6, blz. 861-864. https://doi.org/10.1111/bjh.12329

No significant prognostic value of normal precursor B-cell regeneration in paediatric acute myeloid leukaemia after induction treatment. / Bras, Anne E.; Van den Heuvel-Eibrink, Marry M.; Van der Sluijs-Gelling, Alita J. et al.
In: British Journal of Haematology, Vol. 161, Nr. 6, 06.2013, blz. 861-864.

Onderzoeksoutput: Bijdrage aan tijdschrift › Artikel › peer review

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T1 - No significant prognostic value of normal precursor B-cell regeneration in paediatric acute myeloid leukaemia after induction treatment

AU - Bras, Anne E.

AU - Van den Heuvel-Eibrink, Marry M.

AU - Van der Sluijs-Gelling, Alita J.

AU - Coenen, Eva A.

AU - Wind, Henk

AU - Zwaan, C. Michel

AU - Te Marvelde, Jeroen G.

AU - Van der Burg, Mirjam

AU - Gibson, Brenda

AU - Rijneveld, Anita W.

AU - De Haas, Valérie

AU - Van Dongen, Jacques J.M.

AU - Van der Velden, Vincent H.J.

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AB - B-cell precursors (BCP) regeneration in bone marrow (BM) after induction chemotherapy is prognostic for good treatment response in adult acute myeloid leukaemia (AML). We detected BCP regeneration in 81% of 59 paediatric AML patients at first complete remission; this compared to 46% in an adult study. BCP regeneration did not correlate with outcome or minimal residual disease levels. In 36 healthy BM controls, BCP levels were significantly higher in children as compared to adults. Therefore, BCP regeneration does not reflect good response to treatment in paediatric AML, possibly due to the relatively high base-line levels of BCP in children.

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No significant prognostic value of normal precursor B-cell regeneration in paediatric acute myeloid leukaemia after induction treatment

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