Nonparameningeal head and neck rhabdomyosarcoma in children and adolescents: Lessons from the consecutive International Society of Pediatric Oncology Malignant Mesenchymal Tumor studies

Daniel Orbach; Veronique Mosseri; Soledad Gallego; Anna Kelsey; Christine Devalck; Bernadette Brenann; Max M van Noesel; Christophe Bergeron; Johannes H M Merks; Catherine Rechnitzer; Meriel Jenney; Veronique Minard-Colin; Michael Stevens

doi:10.1002/hed.24547

Nonparameningeal head and neck rhabdomyosarcoma in children and adolescents: Lessons from the consecutive International Society of Pediatric Oncology Malignant Mesenchymal Tumor studies

Daniel Orbach, Veronique Mosseri, Soledad Gallego, Anna Kelsey, Christine Devalck, Bernadette Brenann, Max M van Noesel, Christophe Bergeron, Johannes H M Merks, Catherine Rechnitzer, Meriel Jenney, Veronique Minard-Colin, Michael Stevens

Group van Noesel

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BACKGROUND: This article reports risk factors and long-term outcome in localized nonparameningeal head and neck rhabdomyosarcomas in children and adolescents from a combined dataset from 3 consecutive international trials.

METHODS: Data from 140 children (9.3% of total) prospectively enrolled in the International Society of Pediatric Oncology Malignant Mesenchymal Tumor (SIOP-MMT)-84/89/95 studies were analyzed.

RESULTS: Primary site was: superficial face in 46%; oral cavity (21%); neck (19%); and salivary glands (14%). Local control was achieved in 96%, but 49% relapsed (locoregionally 91%). At median follow-up of 10 years, 5-year overall survival (OS) was 74.7% (67.4% to 81.9%) and event-free survival 48.9% (40.6% to 57.2%), although this improved with successive studies. Radiotherapy (RT) as first-line treatment was independently prognostic for event-free survival (relative risk [RR] = 0.4 [range, 0.2-0.7]; p < .01) even if it did not impact OS (RR = 1 [range, 0.5-2]).

CONCLUSION: High rates of locoregional relapse were seen in head and neck rhabdomyosarcoma that should be prevented by more frequent use of RT in this primary. © 2016 Wiley Periodicals, Inc. Head Neck 39: 24-31, 2017.

Originele taal-2	Engels
Pagina's (van-tot)	24-31
Aantal pagina's	8
Tijdschrift	Head & neck
Volume	39
Nummer van het tijdschrift	1
DOI's	https://doi.org/10.1002/hed.24547
Status	Gepubliceerd - jan. 2017

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10.1002/hed.24547

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Orbach, D., Mosseri, V., Gallego, S., Kelsey, A., Devalck, C., Brenann, B., van Noesel, M. M., Bergeron, C., Merks, J. H. M., Rechnitzer, C., Jenney, M., Minard-Colin, V., & Stevens, M. (2017). Nonparameningeal head and neck rhabdomyosarcoma in children and adolescents: Lessons from the consecutive International Society of Pediatric Oncology Malignant Mesenchymal Tumor studies. Head & neck, 39(1), 24-31. https://doi.org/10.1002/hed.24547

@article{43d2dab710b34ebe825ae7f3b6dbe207,

title = "Nonparameningeal head and neck rhabdomyosarcoma in children and adolescents: Lessons from the consecutive International Society of Pediatric Oncology Malignant Mesenchymal Tumor studies",

abstract = "BACKGROUND: This article reports risk factors and long-term outcome in localized nonparameningeal head and neck rhabdomyosarcomas in children and adolescents from a combined dataset from 3 consecutive international trials.METHODS: Data from 140 children (9.3% of total) prospectively enrolled in the International Society of Pediatric Oncology Malignant Mesenchymal Tumor (SIOP-MMT)-84/89/95 studies were analyzed.RESULTS: Primary site was: superficial face in 46%; oral cavity (21%); neck (19%); and salivary glands (14%). Local control was achieved in 96%, but 49% relapsed (locoregionally 91%). At median follow-up of 10 years, 5-year overall survival (OS) was 74.7% (67.4% to 81.9%) and event-free survival 48.9% (40.6% to 57.2%), although this improved with successive studies. Radiotherapy (RT) as first-line treatment was independently prognostic for event-free survival (relative risk [RR] = 0.4 [range, 0.2-0.7]; p < .01) even if it did not impact OS (RR = 1 [range, 0.5-2]).CONCLUSION: High rates of locoregional relapse were seen in head and neck rhabdomyosarcoma that should be prevented by more frequent use of RT in this primary. {\textcopyright} 2016 Wiley Periodicals, Inc. Head Neck 39: 24-31, 2017.",

keywords = "Adolescent, Child, Child, Preschool, Combined Modality Therapy, Disease-Free Survival, Female, Head and Neck Neoplasms/mortality, Humans, Infant, Infant, Newborn, Male, Mesenchymoma/mortality, Neoplasm Recurrence, Local/epidemiology, Retrospective Studies, Rhabdomyosarcoma/mortality, Risk Factors, Survival Rate, Treatment Outcome",

author = "Daniel Orbach and Veronique Mosseri and Soledad Gallego and Anna Kelsey and Christine Devalck and Bernadette Brenann and {van Noesel}, {Max M} and Christophe Bergeron and Merks, {Johannes H M} and Catherine Rechnitzer and Meriel Jenney and Veronique Minard-Colin and Michael Stevens",

note = "{\textcopyright} 2016 Wiley Periodicals, Inc.",

year = "2017",

month = jan,

doi = "10.1002/hed.24547",

language = "English",

volume = "39",

pages = "24--31",

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Orbach, D, Mosseri, V, Gallego, S, Kelsey, A, Devalck, C, Brenann, B, van Noesel, MM, Bergeron, C, Merks, JHM, Rechnitzer, C, Jenney, M, Minard-Colin, V & Stevens, M 2017, 'Nonparameningeal head and neck rhabdomyosarcoma in children and adolescents: Lessons from the consecutive International Society of Pediatric Oncology Malignant Mesenchymal Tumor studies', Head & neck, vol. 39, nr. 1, blz. 24-31. https://doi.org/10.1002/hed.24547

Nonparameningeal head and neck rhabdomyosarcoma in children and adolescents: Lessons from the consecutive International Society of Pediatric Oncology Malignant Mesenchymal Tumor studies. / Orbach, Daniel; Mosseri, Veronique; Gallego, Soledad et al.
In: Head & neck, Vol. 39, Nr. 1, 01.2017, blz. 24-31.

Onderzoeksoutput: Bijdrage aan tijdschrift › Artikel › peer review

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T1 - Nonparameningeal head and neck rhabdomyosarcoma in children and adolescents

T2 - Lessons from the consecutive International Society of Pediatric Oncology Malignant Mesenchymal Tumor studies

AU - Orbach, Daniel

AU - Mosseri, Veronique

AU - Gallego, Soledad

AU - Kelsey, Anna

AU - Devalck, Christine

AU - Brenann, Bernadette

AU - van Noesel, Max M

AU - Bergeron, Christophe

AU - Merks, Johannes H M

AU - Rechnitzer, Catherine

AU - Jenney, Meriel

AU - Minard-Colin, Veronique

AU - Stevens, Michael

PY - 2017/1

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N2 - BACKGROUND: This article reports risk factors and long-term outcome in localized nonparameningeal head and neck rhabdomyosarcomas in children and adolescents from a combined dataset from 3 consecutive international trials.METHODS: Data from 140 children (9.3% of total) prospectively enrolled in the International Society of Pediatric Oncology Malignant Mesenchymal Tumor (SIOP-MMT)-84/89/95 studies were analyzed.RESULTS: Primary site was: superficial face in 46%; oral cavity (21%); neck (19%); and salivary glands (14%). Local control was achieved in 96%, but 49% relapsed (locoregionally 91%). At median follow-up of 10 years, 5-year overall survival (OS) was 74.7% (67.4% to 81.9%) and event-free survival 48.9% (40.6% to 57.2%), although this improved with successive studies. Radiotherapy (RT) as first-line treatment was independently prognostic for event-free survival (relative risk [RR] = 0.4 [range, 0.2-0.7]; p < .01) even if it did not impact OS (RR = 1 [range, 0.5-2]).CONCLUSION: High rates of locoregional relapse were seen in head and neck rhabdomyosarcoma that should be prevented by more frequent use of RT in this primary. © 2016 Wiley Periodicals, Inc. Head Neck 39: 24-31, 2017.

AB - BACKGROUND: This article reports risk factors and long-term outcome in localized nonparameningeal head and neck rhabdomyosarcomas in children and adolescents from a combined dataset from 3 consecutive international trials.METHODS: Data from 140 children (9.3% of total) prospectively enrolled in the International Society of Pediatric Oncology Malignant Mesenchymal Tumor (SIOP-MMT)-84/89/95 studies were analyzed.RESULTS: Primary site was: superficial face in 46%; oral cavity (21%); neck (19%); and salivary glands (14%). Local control was achieved in 96%, but 49% relapsed (locoregionally 91%). At median follow-up of 10 years, 5-year overall survival (OS) was 74.7% (67.4% to 81.9%) and event-free survival 48.9% (40.6% to 57.2%), although this improved with successive studies. Radiotherapy (RT) as first-line treatment was independently prognostic for event-free survival (relative risk [RR] = 0.4 [range, 0.2-0.7]; p < .01) even if it did not impact OS (RR = 1 [range, 0.5-2]).CONCLUSION: High rates of locoregional relapse were seen in head and neck rhabdomyosarcoma that should be prevented by more frequent use of RT in this primary. © 2016 Wiley Periodicals, Inc. Head Neck 39: 24-31, 2017.

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KW - Disease-Free Survival

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KW - Humans

KW - Infant

KW - Infant, Newborn

KW - Male

KW - Mesenchymoma/mortality

KW - Neoplasm Recurrence, Local/epidemiology

KW - Retrospective Studies

KW - Rhabdomyosarcoma/mortality

KW - Risk Factors

KW - Survival Rate

KW - Treatment Outcome

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DO - 10.1002/hed.24547

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SN - 1043-3074

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JO - Head & neck

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Nonparameningeal head and neck rhabdomyosarcoma in children and adolescents: Lessons from the consecutive International Society of Pediatric Oncology Malignant Mesenchymal Tumor studies

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