Notch ligand Dll1 mediates cross-talk between mammary stem cells and the macrophageal niche

Rumela Chakrabarti; Toni Celià-Terrassa; Sushil Kumar; Xiang Hang; Yong Wei; Abrar Choudhury; Julie Hwang; Jia Peng; Briana Nixon; John J. Grady; Christina DeCoste; Jie Gao; Johan H. van Es; Ming O. Li; Iannis Aifantis; Hans Clevers; Yibin Kang

doi:10.1126/science.aan4153

Notch ligand Dll1 mediates cross-talk between mammary stem cells and the macrophageal niche

Rumela Chakrabarti, Toni Celià-Terrassa, Sushil Kumar, Xiang Hang, Yong Wei, Abrar Choudhury, Julie Hwang, Jia Peng, Briana Nixon, John J. Grady, Christina DeCoste, Jie Gao, Johan H. van Es, Ming O. Li, Iannis Aifantis, Hans Clevers, Yibin Kang

Onderzoeksoutput: Bijdrage aan tijdschrift › Artikel › peer review

144 Citaten (Scopus)

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The stem cell niche is a specialized environment that dictates stem cell function during development and homeostasis. We show that Dll1, a Notch pathway ligand, is enriched in mammary gland stem cells (MaSCs) and mediates critical interactions with stromal macrophages in the surrounding niche in mouse models. Conditional deletion of Dll1 reduced the number of MaSCs and impaired ductal morphogenesis in the mammary gland. Moreover, MaSC-expressed Dll1 activates Notch signaling in stromal macrophages, increasing their expression of Wnt family ligands such as Wnt3, Wnt10A, and Wnt16, thereby initiating a feedback loop that promotes the function of Dll1-expressing MaSCs. Together, these findings reveal functionally important cross-talk between MaSCs and their macrophageal niche through Dll1-mediated Notch signaling.

Originele taal-2	Engels
Artikelnummer	eaan4153
Tijdschrift	Science
Volume	360
Nummer van het tijdschrift	6396
DOI's	https://doi.org/10.1126/science.aan4153
Status	Gepubliceerd - 29 jun. 2018
Extern gepubliceerd	Ja

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Chakrabarti, R., Celià-Terrassa, T., Kumar, S., Hang, X., Wei, Y., Choudhury, A., Hwang, J., Peng, J., Nixon, B., Grady, J. J., DeCoste, C., Gao, J., van Es, J. H., Li, M. O., Aifantis, I., Clevers, H., & Kang, Y. (2018). Notch ligand Dll1 mediates cross-talk between mammary stem cells and the macrophageal niche. Science, 360(6396), Artikel eaan4153. https://doi.org/10.1126/science.aan4153

@article{4d66284035034ca19857a8228f5314d8,

title = "Notch ligand Dll1 mediates cross-talk between mammary stem cells and the macrophageal niche",

abstract = "The stem cell niche is a specialized environment that dictates stem cell function during development and homeostasis. We show that Dll1, a Notch pathway ligand, is enriched in mammary gland stem cells (MaSCs) and mediates critical interactions with stromal macrophages in the surrounding niche in mouse models. Conditional deletion of Dll1 reduced the number of MaSCs and impaired ductal morphogenesis in the mammary gland. Moreover, MaSC-expressed Dll1 activates Notch signaling in stromal macrophages, increasing their expression of Wnt family ligands such as Wnt3, Wnt10A, and Wnt16, thereby initiating a feedback loop that promotes the function of Dll1-expressing MaSCs. Together, these findings reveal functionally important cross-talk between MaSCs and their macrophageal niche through Dll1-mediated Notch signaling.",

author = "Rumela Chakrabarti and Toni Celi{\`a}-Terrassa and Sushil Kumar and Xiang Hang and Yong Wei and Abrar Choudhury and Julie Hwang and Jia Peng and Briana Nixon and Grady, {John J.} and Christina DeCoste and Jie Gao and {van Es}, {Johan H.} and Li, {Ming O.} and Iannis Aifantis and Hans Clevers and Yibin Kang",

note = "Publisher Copyright: {\textcopyright} 2017 The Authors.",

year = "2018",

month = jun,

day = "29",

doi = "10.1126/science.aan4153",

language = "English",

volume = "360",

journal = "Science",

issn = "0036-8075",

publisher = "American Association for the Advancement of Science",

number = "6396",

}

Chakrabarti, R, Celià-Terrassa, T, Kumar, S, Hang, X, Wei, Y, Choudhury, A, Hwang, J, Peng, J, Nixon, B, Grady, JJ, DeCoste, C, Gao, J, van Es, JH, Li, MO, Aifantis, I, Clevers, H & Kang, Y 2018, 'Notch ligand Dll1 mediates cross-talk between mammary stem cells and the macrophageal niche', Science, vol. 360, nr. 6396, eaan4153. https://doi.org/10.1126/science.aan4153

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T1 - Notch ligand Dll1 mediates cross-talk between mammary stem cells and the macrophageal niche

AU - Chakrabarti, Rumela

AU - Celià-Terrassa, Toni

AU - Kumar, Sushil

AU - Hang, Xiang

AU - Wei, Yong

AU - Choudhury, Abrar

AU - Hwang, Julie

AU - Peng, Jia

AU - Nixon, Briana

AU - Grady, John J.

AU - DeCoste, Christina

AU - Gao, Jie

AU - van Es, Johan H.

AU - Li, Ming O.

AU - Aifantis, Iannis

AU - Clevers, Hans

AU - Kang, Yibin

PY - 2018/6/29

Y1 - 2018/6/29

N2 - The stem cell niche is a specialized environment that dictates stem cell function during development and homeostasis. We show that Dll1, a Notch pathway ligand, is enriched in mammary gland stem cells (MaSCs) and mediates critical interactions with stromal macrophages in the surrounding niche in mouse models. Conditional deletion of Dll1 reduced the number of MaSCs and impaired ductal morphogenesis in the mammary gland. Moreover, MaSC-expressed Dll1 activates Notch signaling in stromal macrophages, increasing their expression of Wnt family ligands such as Wnt3, Wnt10A, and Wnt16, thereby initiating a feedback loop that promotes the function of Dll1-expressing MaSCs. Together, these findings reveal functionally important cross-talk between MaSCs and their macrophageal niche through Dll1-mediated Notch signaling.

AB - The stem cell niche is a specialized environment that dictates stem cell function during development and homeostasis. We show that Dll1, a Notch pathway ligand, is enriched in mammary gland stem cells (MaSCs) and mediates critical interactions with stromal macrophages in the surrounding niche in mouse models. Conditional deletion of Dll1 reduced the number of MaSCs and impaired ductal morphogenesis in the mammary gland. Moreover, MaSC-expressed Dll1 activates Notch signaling in stromal macrophages, increasing their expression of Wnt family ligands such as Wnt3, Wnt10A, and Wnt16, thereby initiating a feedback loop that promotes the function of Dll1-expressing MaSCs. Together, these findings reveal functionally important cross-talk between MaSCs and their macrophageal niche through Dll1-mediated Notch signaling.

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DO - 10.1126/science.aan4153

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SN - 0036-8075

VL - 360

JO - Science

JF - Science

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Notch ligand Dll1 mediates cross-talk between mammary stem cells and the macrophageal niche

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