Nuclear factor I/B is an oncogene in small cell lung cancer

Alison L. Dooley, Monte M. Winslow, Derek Y. Chiang, Shantanu Banerji, Nicolas Stransky, Talya L. Dayton, Eric L. Snyder, Stephanie Senna, Charles A. Whittaker, Roderick T. Bronson, Denise Crowley, Jordi Barretina, Levi Garraway, Matthew Meyerson, Tyler Jacks

Onderzoeksoutput: Bijdrage aan tijdschriftArtikelpeer review

136 Citaten (Scopus)

Samenvatting

Small cell lung cancer (SCLC) is an aggressive cancer often diagnosed after it has metastasized. Despite the need to better understand this disease, SCLC remains poorly characterized at the molecular and genomic levels. Using a genetically engineered mouse model of SCLC driven by conditional deletion of Trp53 and Rb1 in the lung, we identified several frequent, high-magnitude focal DNA copy number alterations in SCLC. We uncovered amplification of a novel, oncogenic transcription factor, Nuclear factor I/B (Nfib), in the mouse SCLC model and in human SCLC. Functional studies indicate that NFIB regulates cell viability and proliferation during transformation.

Originele taal-2Engels
Pagina's (van-tot)1470-1475
Aantal pagina's6
TijdschriftGenes and Development
Volume25
Nummer van het tijdschrift14
DOI's
StatusGepubliceerd - 15 jul. 2011
Extern gepubliceerdJa

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