Nuclear factor I/B is an oncogene in small cell lung cancer

Alison L. Dooley; Monte M. Winslow; Derek Y. Chiang; Shantanu Banerji; Nicolas Stransky; Talya L. Dayton; Eric L. Snyder; Stephanie Senna; Charles A. Whittaker; Roderick T. Bronson; Denise Crowley; Jordi Barretina; Levi Garraway; Matthew Meyerson; Tyler Jacks

doi:10.1101/gad.2046711

Nuclear factor I/B is an oncogene in small cell lung cancer

Alison L. Dooley, Monte M. Winslow, Derek Y. Chiang, Shantanu Banerji, Nicolas Stransky, Talya L. Dayton, Eric L. Snyder, Stephanie Senna, Charles A. Whittaker, Roderick T. Bronson, Denise Crowley, Jordi Barretina, Levi Garraway, Matthew Meyerson, Tyler Jacks

Onderzoeksoutput: Bijdrage aan tijdschrift › Artikel › peer review

141 Citaten (Scopus)

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Small cell lung cancer (SCLC) is an aggressive cancer often diagnosed after it has metastasized. Despite the need to better understand this disease, SCLC remains poorly characterized at the molecular and genomic levels. Using a genetically engineered mouse model of SCLC driven by conditional deletion of Trp53 and Rb1 in the lung, we identified several frequent, high-magnitude focal DNA copy number alterations in SCLC. We uncovered amplification of a novel, oncogenic transcription factor, Nuclear factor I/B (Nfib), in the mouse SCLC model and in human SCLC. Functional studies indicate that NFIB regulates cell viability and proliferation during transformation.

Originele taal-2	Engels
Pagina's (van-tot)	1470-1475
Aantal pagina's	6
Tijdschrift	Genes and Development
Volume	25
Nummer van het tijdschrift	14
DOI's	https://doi.org/10.1101/gad.2046711
Status	Gepubliceerd - 15 jul. 2011
Extern gepubliceerd	Ja

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title = "Nuclear factor I/B is an oncogene in small cell lung cancer",

abstract = "Small cell lung cancer (SCLC) is an aggressive cancer often diagnosed after it has metastasized. Despite the need to better understand this disease, SCLC remains poorly characterized at the molecular and genomic levels. Using a genetically engineered mouse model of SCLC driven by conditional deletion of Trp53 and Rb1 in the lung, we identified several frequent, high-magnitude focal DNA copy number alterations in SCLC. We uncovered amplification of a novel, oncogenic transcription factor, Nuclear factor I/B (Nfib), in the mouse SCLC model and in human SCLC. Functional studies indicate that NFIB regulates cell viability and proliferation during transformation.",

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AU - Dooley, Alison L.

AU - Winslow, Monte M.

AU - Chiang, Derek Y.

AU - Banerji, Shantanu

AU - Stransky, Nicolas

AU - Dayton, Talya L.

AU - Snyder, Eric L.

AU - Senna, Stephanie

AU - Whittaker, Charles A.

AU - Bronson, Roderick T.

AU - Crowley, Denise

AU - Barretina, Jordi

AU - Garraway, Levi

AU - Meyerson, Matthew

AU - Jacks, Tyler

PY - 2011/7/15

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N2 - Small cell lung cancer (SCLC) is an aggressive cancer often diagnosed after it has metastasized. Despite the need to better understand this disease, SCLC remains poorly characterized at the molecular and genomic levels. Using a genetically engineered mouse model of SCLC driven by conditional deletion of Trp53 and Rb1 in the lung, we identified several frequent, high-magnitude focal DNA copy number alterations in SCLC. We uncovered amplification of a novel, oncogenic transcription factor, Nuclear factor I/B (Nfib), in the mouse SCLC model and in human SCLC. Functional studies indicate that NFIB regulates cell viability and proliferation during transformation.

AB - Small cell lung cancer (SCLC) is an aggressive cancer often diagnosed after it has metastasized. Despite the need to better understand this disease, SCLC remains poorly characterized at the molecular and genomic levels. Using a genetically engineered mouse model of SCLC driven by conditional deletion of Trp53 and Rb1 in the lung, we identified several frequent, high-magnitude focal DNA copy number alterations in SCLC. We uncovered amplification of a novel, oncogenic transcription factor, Nuclear factor I/B (Nfib), in the mouse SCLC model and in human SCLC. Functional studies indicate that NFIB regulates cell viability and proliferation during transformation.

KW - Mouse model

KW - Nuclear factor I/B

KW - Small cell lung cancer

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Nuclear factor I/B is an oncogene in small cell lung cancer

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