Nuclear factor one B (NFIB) encodes a subtype-specific tumour suppressor in glioblastoma

Brett W. Stringer, Jens Bunt, Bryan W. Day, Guy Barry, Paul R. Jamieson, Kathleen S. Ensbey, Zara C. Bruce, Kate Goasdoué, Hélène Vidal, Sara Charmsaz, Fiona M. Smith, Leanne T. Cooper, Michael Piper, Andrew W. Boyd, Linda J. Richards

Onderzoeksoutput: Bijdrage aan tijdschriftArtikelpeer review

Samenvatting

Glioblastoma (GBM) is an essentially incurable and rapidly fatal cancer, with few markers predicting a favourable prognosis. Here we report that the transcription factor NFIB is associated with significantly improved survival in GBM. NFIB expression correlates inversely with astrocytoma grade and is lowest in mesenchymal GBM. Ectopic expression of NFIB in low-passage, patient-derived classical and mesenchymal subtype GBM cells inhibits tumourigenesis. Ectopic NFIB expression activated phospho-STAT3 signalling only in classical and mesenchymal GBM cells, suggesting a mechanism through which NFIB may exert its context-dependent tumour suppressor activity. Finally, NFIB expression can be induced in GBM cells by drug treatment with beneficial effects.
Originele taal-2Engels
Pagina's (van-tot)29306-29320
Aantal pagina's15
TijdschriftOncotarget
Volume7
Nummer van het tijdschrift20
DOI's
StatusGepubliceerd - 17 mei 2016
Extern gepubliceerdJa

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