Oncogene activation and oncogene cooperation in MMTV-induced mouse mammary cancer

F van Leeuwen, R Nusse

Onderzoeksoutput: Bijdrage aan tijdschriftArtikel recenserenpeer review

Samenvatting

In this short review, we will give an overview of the various genes that can be activated by insertion of proviral DNA of the mouse mammary tumor virus during the formation of mammary cancer. These genes fall within three families: Wnt genes, FGF genes and Notch-related genes. We will summarize our current understanding of the roles of these genes in tumorigenesis and in normal development, and the mechanisms of action of their gene products. Finally, we will give some examples of cooperation between these genes in various biological settings.

Originele taal-2Engels
Pagina's (van-tot)127-33
Aantal pagina's7
TijdschriftSeminars in cancer biology
Volume6
Nummer van het tijdschrift3
DOI's
StatusGepubliceerd - jun. 1995
Extern gepubliceerdJa

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