One hundred consecutive isolated limb perfusions with TNF-α and melphalan in melanoma patients with multiple in-transit metastases

Dirk J. Grünhagen, Flavia Brunstein, Wilfried J. Graveland, Albertus N. Van Geel, Johannes H.W. De Wilt, Alexander M.M. Eggermont, Borel Rinkes

Onderzoeksoutput: Bijdrage aan tijdschriftArtikelpeer review

111 Citaten (Scopus)

Samenvatting

Objective: The aim of this study is to describe the experience with 100 TNF-based ILP for locally advanced melanoma and to determine prognostic factors for response, time to local progression, and survival. Methods: One hundred TNF-based ILPs were performed between 1991 and 2003 in 87 patients for whom local control by surgery of in-transit melanoma metastases was impossible. In total, 62 iliac, 33 femoral, and 5 axillary ILPs were performed in mild hyperthermic conditions with 2 to 4 mg of TNF and 10 to 13 mg of melphalan per liter of limb volume. Results: Overall response was 95%, with 69% complete response, 26% partial response, and 5% no change. Complete response rate differed significantly for patients with IIIA disease versus IIIAB and IV. Local and systemic toxicity was mild to moderate in almost all cases, with no treatment-related death and one treatment-related amputation. Five-year overall survival was 32%; local progression occurred in 55% after a median of 16 months. In complete response patients, 5-year survival was 42% with local progression in 52% at a median of 22 months. Response rate and survival were significantly influenced by stage of disease; (local progression free) survival was influenced by response rate. Conclusions: TNF-based ILP results in excellent response rates in this patient population with unfavorable characteristics. Response on ILP predicts outcome in patients and reflects aggressiveness of the tumor.

Originele taal-2Engels
Pagina's (van-tot)939-948
Aantal pagina's10
TijdschriftAnnals of Surgery
Volume240
Nummer van het tijdschrift6
DOI's
StatusGepubliceerd - dec. 2004
Extern gepubliceerdJa

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