Organoid cultures for the analysis of cancer phenotypes

Norman Sachs, Hans Clevers

Onderzoeksoutput: Bijdrage aan tijdschriftArtikel recenserenpeer review

265 Citaten (Scopus)


Preclinical models of cancer are essential for a basic understanding of cancer biology and its translation into efficient treatment options for affected patients. Cancer cell lines and xenografts derived directly from primary human tumors have proven very valuable in fundamental oncology research and anticancer drug discovery. Both models inherently comprise advantages and caveats that have to be accounted for. We will outline in these and discuss primary patient derived organoids as third preclinical cancer model. We propose that cancer organoids could potentially fill the gap between simple cancer cell lines suitable for high-throughput screens and complicated, but physiologically relevant xenografts. The resulting applications for cancer organoids range from basic research to drug screens and patient stratification.

Originele taal-2Engels
Pagina's (van-tot)68-73
Aantal pagina's6
TijdschriftCurrent Opinion in Genetics and Development
Nummer van het tijdschrift1
StatusGepubliceerd - feb. 2014
Extern gepubliceerdJa


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