TY - JOUR
T1 - Organoids in immunological research
AU - Bar-Ephraim, Yotam E.
AU - Kretzschmar, Kai
AU - Clevers, Hans
N1 - Publisher Copyright:
© 2019, Springer Nature Limited.
PY - 2020/5/1
Y1 - 2020/5/1
N2 - Much of our knowledge regarding the interactions between epithelial tissues and the immune system has been gathered from animal models and co-cultures with cell lines. However, unique features of human cells cannot be modelled in mice, and cell lines are often transformed or genetically immortalized. Organoid technology has emerged as a powerful tool to maintain epithelial cells in a near-native state. In this Review, we discuss how organoids are being used in immunological research to understand the role of epithelial cell–immune cell interactions in tissue development and homeostasis, as well as in diseases such as cancer.
AB - Much of our knowledge regarding the interactions between epithelial tissues and the immune system has been gathered from animal models and co-cultures with cell lines. However, unique features of human cells cannot be modelled in mice, and cell lines are often transformed or genetically immortalized. Organoid technology has emerged as a powerful tool to maintain epithelial cells in a near-native state. In this Review, we discuss how organoids are being used in immunological research to understand the role of epithelial cell–immune cell interactions in tissue development and homeostasis, as well as in diseases such as cancer.
UR - http://www.scopus.com/inward/record.url?scp=85077029579&partnerID=8YFLogxK
U2 - 10.1038/s41577-019-0248-y
DO - 10.1038/s41577-019-0248-y
M3 - Review article
C2 - 31853049
AN - SCOPUS:85077029579
SN - 1474-1733
VL - 20
SP - 279
EP - 293
JO - Nature Reviews Immunology
JF - Nature Reviews Immunology
IS - 5
ER -