TY - JOUR
T1 - Outcome after treatment with axitinib in children, young adults, and adults with renal cell carcinoma
T2 - a narrative review
AU - Sprokkerieft, Julia
AU - van der Beek, Justine N.
AU - Spreafico, Filippo
AU - Selle, Barbara
AU - Chowdhury, Tanzina
AU - Graf, Norbert
AU - Verschuur, Arnauld C.
AU - Dandis, Rana
AU - Bex, Axel
AU - Geller, James I.
AU - Tytgat, Godelieve A.M.
AU - van den Heuvel-Eibrink, Marry M.
N1 - Publisher Copyright:
© 2024 The Authors
PY - 2024/12
Y1 - 2024/12
N2 - Renal cell carcinoma (RCC) is a very rare type of renal cancer in children and young adults. When metastasized or recurrent, no standards of care are available, and outcome is still poor. The tyrosine kinase inhibitor axitinib is approved for treatment of RCC in adults, but its effects in children and young adults with RCC remains unclear. Due to the histological and biological differences between children and adults, it is difficult to extrapolate knowledge on treatments from the adult to the pediatric and young adult setting. This paper summarizes the clinical characteristics and outcomes of patients with RCC who were treated with axitinib, with the aim to gain insight in the clinical efficacy of this compound in this young patient group.
AB - Renal cell carcinoma (RCC) is a very rare type of renal cancer in children and young adults. When metastasized or recurrent, no standards of care are available, and outcome is still poor. The tyrosine kinase inhibitor axitinib is approved for treatment of RCC in adults, but its effects in children and young adults with RCC remains unclear. Due to the histological and biological differences between children and adults, it is difficult to extrapolate knowledge on treatments from the adult to the pediatric and young adult setting. This paper summarizes the clinical characteristics and outcomes of patients with RCC who were treated with axitinib, with the aim to gain insight in the clinical efficacy of this compound in this young patient group.
KW - Pediatric
KW - axitinib
KW - renal cell carcinoma
KW - young adult
UR - https://www.scopus.com/pages/publications/85206475618
U2 - 10.1016/j.critrevonc.2024.104523
DO - 10.1016/j.critrevonc.2024.104523
M3 - Review article
C2 - 39326645
AN - SCOPUS:85206475618
SN - 1040-8428
VL - 204
JO - Critical Reviews in Oncology/Hematology
JF - Critical Reviews in Oncology/Hematology
M1 - 104523
ER -