TY - JOUR
T1 - Outcome of Cataract Surgery in Patients With Retinitis Pigmentosa
AU - Nguyen, Xuan Thanh An
AU - Thiadens, Alberta A.H.J.
AU - Fiocco, Marta
AU - Tan, Weijen
AU - McKibbin, Martin
AU - Klaver, Caroline C.W.
AU - Meester-Smoor, Magda A.
AU - Van Cauwenbergh, Caroline
AU - Strubbe, Ine
AU - Vergaro, Andrea
AU - Pott, Jan Willem R.
AU - Hoyng, Carel B.
AU - Leroy, Bart P.
AU - Zemaitiene, Reda
AU - Khan, Kamron N.
AU - Boon, Camiel J.F.
N1 - Copyright © 2022 The Author(s). Published by Elsevier Inc. All rights reserved.
PY - 2023/2
Y1 - 2023/2
N2 - PURPOSE: To assess the visual outcome of cataract surgery in patients with retinitis pigmentosa (RP).DESIGN: Retrospective, noncomparative clinical study.METHODS: Preoperative, intraoperative, and postoperative data of patients with RP who were undergoing cataract surgery were collected from several expertise centers across Europe.RESULTS: In total, 295 eyes of 226 patients were included in the study. The mean age at surgery of the first eye was 56.1 ± 17.9 years. Following surgery, best-corrected visual acuity (BCVA) improved significantly from 1.03 to 0.81 logMAR (ie, 20/214 to 20/129 Snellen) in the first treated eye (-0.22 logMAR; 95% CI = -0.31 to -0.13; P < .001) and from 0.80 to 0.56 logMAR (ie, 20/126 to 20/73 Snellen) in the second treated eye (-0.24 logMAR; 95% CI = -0.32 to -0.15; P < .001). Marked BCVA improvements (postoperative change in BCVA of ≥0.3 logMAR) were observed in 87 of 226 patients (39%). Greater odds for marked visual improvements were observed in patients with moderate visual impairment or worse. The most common complications were zonular dialysis (n = 15; 5%) and (exacerbation of) cystoid macular edema (n = 14; 5%), respectively. Postoperative posterior capsular opacifications were present in 111 of 295 eyes (38%).CONCLUSION: Significant improvements in BCVA are observed in most patients with RP following cataract surgery. Baseline BCVA is a predictor of visual outcome. Preoperative evaluation should include the assessment of potential zonular insufficiency and the presence of CME, as they are relatively common and may increase the risk of complications.
AB - PURPOSE: To assess the visual outcome of cataract surgery in patients with retinitis pigmentosa (RP).DESIGN: Retrospective, noncomparative clinical study.METHODS: Preoperative, intraoperative, and postoperative data of patients with RP who were undergoing cataract surgery were collected from several expertise centers across Europe.RESULTS: In total, 295 eyes of 226 patients were included in the study. The mean age at surgery of the first eye was 56.1 ± 17.9 years. Following surgery, best-corrected visual acuity (BCVA) improved significantly from 1.03 to 0.81 logMAR (ie, 20/214 to 20/129 Snellen) in the first treated eye (-0.22 logMAR; 95% CI = -0.31 to -0.13; P < .001) and from 0.80 to 0.56 logMAR (ie, 20/126 to 20/73 Snellen) in the second treated eye (-0.24 logMAR; 95% CI = -0.32 to -0.15; P < .001). Marked BCVA improvements (postoperative change in BCVA of ≥0.3 logMAR) were observed in 87 of 226 patients (39%). Greater odds for marked visual improvements were observed in patients with moderate visual impairment or worse. The most common complications were zonular dialysis (n = 15; 5%) and (exacerbation of) cystoid macular edema (n = 14; 5%), respectively. Postoperative posterior capsular opacifications were present in 111 of 295 eyes (38%).CONCLUSION: Significant improvements in BCVA are observed in most patients with RP following cataract surgery. Baseline BCVA is a predictor of visual outcome. Preoperative evaluation should include the assessment of potential zonular insufficiency and the presence of CME, as they are relatively common and may increase the risk of complications.
KW - Adult
KW - Aged
KW - Capsule Opacification
KW - Cataract/complications
KW - Humans
KW - Lens Implantation, Intraocular
KW - Middle Aged
KW - Phacoemulsification
KW - Retinitis Pigmentosa/complications
KW - Retrospective Studies
UR - http://www.scopus.com/inward/record.url?scp=85142309973&partnerID=8YFLogxK
U2 - 10.1016/j.ajo.2022.10.001
DO - 10.1016/j.ajo.2022.10.001
M3 - Article
C2 - 36252678
AN - SCOPUS:85142309973
SN - 0002-9394
VL - 246
SP - 1
EP - 9
JO - American Journal of Ophthalmology
JF - American Journal of Ophthalmology
ER -