Outcome of congenital acute lymphoblastic leukemia treated on the Interfant-99 protocol

Marieke H. Van Der Linden, Maria Grazia Valsecchi, Paola De Lorenzo, Anja Möricke, Gritta Janka, Thierry M. Leblanc, Maria Felice, Andrea Biondi, Myriam Campbell, Ian Hann, Jeffrey E. Rubnitz, Jan Stary, Tomasz Szczepanski, Ajay Vora, Alina Ferster, Liisa Hovi, Lewis B. Silverman, Rob Pieters

Onderzoeksoutput: Bijdrage aan tijdschriftArtikelpeer review

73 Citaten (Scopus)


Acute lymphoblastic leukemia (ALL) diagnosed in the first month of life (congenital ALL) is very rare. Although congenital ALL is often assumed to be fatal, no studies have been published on outcome except for case reports. The present study reports the outcome of 30 patients with congenital ALL treated with the uniform Interfant-99 protocol, a hybrid regimen combining ALL treatment with elements designed for treatment of acute myeloid leukemia. Congenital ALL was characterized by a higher white blood cell count and a strong trend for higher incidence ofMLLrearrangements and CD10-negative B-lineageALLcompared with older infants. Induction failure rate was 13% and not significantly different from that in older infants (7%, P = .14), but relapse rate was significantly higher in congenital ALL patients (2-year cumulative incidence [SE] was 60.0 [9.3] vs 34.2 [2.3], P < .001). Two-year event-free survival and survival of congenital ALL patients treated with this protocol was 20% (SE 9.1%). Early death in complete remission and treatment delays resulting from toxicity were not different. The survival of 17% after last follow-up, combined with a toxicity profile comparable with that in older infants, justifies treating congenital ALL with curative intent. This trial was registered at www.clinicaltrials.gov as no. NCT 00015873, and at www.controlled-trials. com as no. ISRCTN24251487.

Originele taal-2Engels
Pagina's (van-tot)3764-3768
Aantal pagina's5
Nummer van het tijdschrift18
StatusGepubliceerd - 29 okt. 2009
Extern gepubliceerdJa


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