Overrepresentation of chromosome 12p sequences and karyotypic evolution in i(12p)-negative testicular germ-cell tumors revealed by fluorescence in situ hybridization

R. F. Suijkerbuijk, R. J. Sinke, A. M. Meloni, J. M. Parrington, J. van Echten, B. de Jong, J. W. Oosterhuis, A. A. Sandberg, A. Geurts van Kessel

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86 Citaten (Scopus)

Samenvatting

Human testicular germ-cell tumors (TGCTs) comprise a heterogeneous group of solid neoplasms. These tumors are characterized by the presence of a highly specific chromosomal abnormality, i.e., an isochromosome of the short arm of chromosome 12. At present, this i(12p) chromosome is found in more than 80% of TGCTs. Isochromosome 12p has also been observed in some ovarian and extragonadal germ cell tumors. In the remaining so-called i(12p)-negative TGCTs other abnormalities involving chromosome 12, mainly 12p, can be found. In order to establish whether 12p abnormalities other than i(12p) are a common phenomenon in TGCTs, a panel of 11 i(12p)-negative tumors was investigated using multicolor fluorescence in situ hybridization. All TGCTs examined appeared to contain chromosomal abnormalities involving 12p, resulting in a distinct overrepresentation of short arm sequences. In addition, indications were obtained for a clonal evolution in one of the tumors. Our data suggest that the occurrence of 12p abnormalities is a common phenomenon in i(12p)-negative TGCTs and that these abnormalities, analogous to i(12p), may contribute to the process of tumor development.

Originele taal-2Engels
Pagina's (van-tot)85-93
Aantal pagina's9
TijdschriftCancer Genetics and Cytogenetics
Volume70
Nummer van het tijdschrift2
DOI's
StatusGepubliceerd - 15 okt. 1993
Extern gepubliceerdJa

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